Image-guided high-dose-rate brachytherapy for prostate cancer patients with previous rectal resection and pelvic irradiation: feasibility study.

Conclusions: Fluoroscopy and 3D CT image-guided interstitial brachytherapy is feasible and appears to be a suitable treatment technique for patients with clinically localized prostate cancer after previous rectal resection and external beam radiation therapy. PMID: 31435432 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

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Up to 60% of patients (pts) with prostate cancer that extends beyond the prostatic capsule will have positive resection margins following radical prostatectomy. Post-operative radiation therapy (PostOp) is routinely offered to those pts. Although this improves local control and overall survival, it results in significantly more late toxicity than surgery alone. Pre-operative radiation therapy (PreOp) has become the standard for soft tissue sarcoma and rectal cancer, improving local control and reducing toxicity compared to PostOp.
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Source Type: research
Abstract BACKGROUND: Specific surgical and oncological outcomes in patients with rectal cancer surgery after a previous diagnosis of prostate cancer have not been well described. The aim of this study was to compare surgical outcomes in patients with rectal cancer with or without a history of prostate cancer. METHODS: Patients who had surgery for rectal cancer with (PC group) or without (no-PC group) previous curative treatment for prostate cancer were enrolled between January 2001 and December 2015. Comparisons between the two groups were performed by multivariable Cox analysis, and after propensity score ma...
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusion Inspired by the general network co-neighbors, this paper proposed the definition of the co-neighbors of the bipartite network based on the hypothesis that that functionally similar miRNAs are related to phenotypically similar diseases. Eight local structural similarity indexes which are co-neighbor, Salton, Jaccard, Sørensen, HPI, HDI, LHN1, and PA were used to measure the association probabilities between nodes. Several types calculation methods of computational miRNA-disease prediction score were introduced, namely, the bipartite network co-neighbor link prediction score using only known association in...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusions: 3D-HDR-BT achieves favorable clinical outcomes with mild late toxicity in patients with locally rNPC. Introduction Nasopharyngeal carcinoma (NPC), a tumor of epithelial origin, is a malignant disease of the head and neck common in southern China, especially in Guangdong province (1). As a result of advances in modern imaging and irradiation techniques, the 5-year overall survival (OS) of patients with newly diagnosed NPC without metastasis has reached 75% after external beam radiotherapy (EBRT) in Asia (2, 3). However, local recurrence, which occurs in 18–40% of patients, remains a major reason for...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: Catching errors prior to treatment is the only way to “chase zero” in radiation oncology. Various types of errors may exist in treatment plans and our GCPR model succeeds in preventing many errors of all shapes and sizes in target definition, dose prescriptions, and treatment plans from ever reaching the patients. Background and Introduction Since the release of the seminal report from the Institute of Medicine (IOM) titled, “To Err is Human,” in 1999, the importance of patient safety and avoiding medical errors have been recognized and endorsed by the physician community, as we...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: The performance of AS AC generally increased as the population of the atlas library increased. However, the performance does not drastically vary in the larger atlas libraries in contrast to the logic that bigger atlas library should lead to better results. In fact, the results do not vary significantly toward the larger atlas library. It is necessary for the institutions to independently research the optimal number of subjects. Introduction Manual contouring of target and critical structures is resource intensive aspect of the radiotherapy planning process. In order to reduce time and workload imposed o...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Much has been researched and written about the promise of PET/MRI. While the...Read more on AuntMinnie.comRelated Reading: Ga-68 PSMA-11 PET/MRI benefits prostate cancer patients TOF PET/MRI makes dose reduction viable for breast cancer How effective is PET/MRI for rectal cancer? PET/MRI with ferumoxytol MR contrast performs well for pediatric patients Cardiac FDG-PET/MRI's role in Anderson-Fabry disease
Source: Headlines - Category: Radiology Source Type: news
ConclusionsIn the combined national population-based registries, a minority of patients with rectal cancer had an AR after previous radiotherapy for prostate cancer. These patients were healthy with early cancer stages and, in this selected group of patients, the AL rate was much lower than that reported previously.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
This study investigates the impact of previous radiation for PCa on survival for patients with RCa.MethodWe conducted a population-based study identifying men who underwent surgical treatment of RCa from 2002 to 2010. Patients were classified into three cohorts: no prior PCa, prior PCa treated without radiotherapy, and prior PCa treated with radiotherapy. The primary outcome was overall survival. Secondary outcomes included RCa surgical approach, ICU admission, length of stay, ER visits, and delayed formation of a new stoma.ResultsSeven thousand ninety-six men underwent surgery for RCa; 6867 patients had no prior PCa, 58 h...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
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