Reduction in pulmonary artery pressures with use of sacubitril/valsartan

Publication date: Available online 23 August 2019Source: Journal of Cardiology CasesAuthor(s): Vincenzo De Simone, Paola Guarise, Gabriele Zanotto, Giorgio MorandoAbstractPulmonary hypertension due to left heart disease (PH-LHD) frequently complicates heart failure with reduced ejection fraction (HFrEF). Specific therapies for PH have not offered an advantage in patients with PH-LHD. The combined angiotensin receptor blocker–neprilysin inhibitor (ARNI), sacubitril/valsartan, is a novel therapy that can increase levels of natriuretic peptides (NPs). The resulting action on natriuresis and vasodilation may play an important role in the reduction of pulmonary pressures. Here, we report how the use of ARNI in two patients with HFrEF has resulted in an improvement in PH and, consequently, in clinical status and prognosis.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research

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