Higher self-reported severity of atopic dermatitis in adults is associated with poorer self-reported health-related quality of life in France, Germany, the UK and the US.
Higher self-reported severity of atopic dermatitis in adults is associated with poorer self-reported health-related quality of life in France, Germany, the UK and the US. Br J Dermatol. 2019 Aug 22;: Authors: Andersen L, Nyeland ME, Nyberg F Abstract BACKGROUND: Better understanding of the relationship between atopic dermatitis (AD) severity and health-related quality of life (HRQoL) could help improve knowledge about the benefits of a more effective treatment of people with AD. OBJECTIVES: To assess the relationship between AD severity and HRQoL as well as with perception of AD symptoms, among adults with moderate-to-severe AD in Europe (France, Germany, and the UK) and the US. METHODS: The survey panel participants for this cross-sectional, internet-based survey in AD adults were recruited from the larger population-based National Health and Wellness Survey (NHWS) (2016 Europe and 2015-2016 US). AD severity was measured by Patient-Oriented SCORing of AD (PO-SCORAD). HRQoL was measured by the 5-level EuroQol-5D version (EQ-5D-5L), Dermatology Life Quality Index (DLQI), and Patient-Oriented Eczema Measure (POEM). RESULTS: 1,232 respondents were included: 1,098 (89.1%) with moderate-to-severe AD (221 [20.1%] from France, 209 [19.0%] Germany, 118 [10.7%] UK, and 550 [50.1%] US); and an additional 134 (10.9%) respondents with mild AD. Sociodemographic and clinical AD characteristics were similar between countries. Among adults with moder...
This article summarizes the most important treatment modalities based on case reports and series, clinical studies, guidelines and expert recommendations. PMID: 31515578 [PubMed - as supplied by publisher]
Authors: Mahler V, Dickel H Abstract The head and hands are the two most common locations for allergic contact dermatitis manifestation. In hand eczema, contact with a contact allergen is a frequent (co-)factor in the triggering and maintenance of eczema. For all hand eczemas lasting longer than 3 months, an allergological examination by means of patch testing is recommended. In patients with allergic contact dermatitis of the hands, nickel, MCI/MI, fragrance mix I, cobalt, thiuram mix, Balsam of Peru, chromium and fragrance mix II have been described in a multicenter European study as...
CONCLUSION: The exact understanding of the individual pathogenesis in single hand eczema patients is essential in order to provide specific advice on allergen avoidance, skin protection and basic treatment and to initiate appropriate therapeutic measures. PMID: 31501971 [PubMed - as supplied by publisher]
Condition: Dermatitis, Atopic Intervention: Drug: BI 655130 Sponsor: Boehringer Ingelheim Not yet recruiting
CONCLUSIONS: Generalized prurigo nodularis is currently also considered as a rather common clinical pattern of adult AD. Dupilumab can be an efficacious treatment of this condition, especially in cases where history of atopy is recorded and conventional treatments are ineffective. PMID: 31517666 [PubMed - as supplied by publisher]
Condition: Dermatitis, Atopic Interventions: Drug: LY3471851; Drug: Placebo Sponsors: Eli Lilly and Company; Nektar Therapeutics Not yet recruiting