Activation-induced cytidine deaminase plays crucial role in ovalbumin-induced food allergy and promoted by IL-21

Publication date: October 2019Source: Molecular Immunology, Volume 114Author(s): Yongning Li, Yongjun Wang, Nanan Sun, Hui Yang, Qiannan Zhang, Xiaopeng Zhang, Run Huang, Xudong JiaAbstractThe prevalence of IgE-mediated food allergy is increasing in the whole wide world which often causes skin and gastrointestinal tract symptoms, or even fatal anaphylactic shock. However, the evaluation of food allergens remains difficult, and the mechanism of food allergy is still not fully clear. To study the gene expression profile in food allergy animal models and identify the regulatory mechanism of the crucial genes, two administration routes were used to build animal models in our study. OVA-specific IgE and IL-4 levels were tested by ELISA, transcriptome profiling was carried out by microarray, and the regulatory mechanism of the highest expressed gene was studied in the primary spleen cells. We found that activation-induced cytidine deaminase (Aicda) is the highest expressed gene in the allergic mice, IL-21 can dramatically enhance the expression of Aicda in the lymph node microenvironment, and IL-17A can promote this effect significantly though it has only limited influence by itself. At last, we illuminated that the promotion of IL-21 on Aicda is partially through STAT3. In summary, our results suggest that IL-21 and IL-17A may play important role in the expression of Aicda as well as food allergy.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research

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Although atopic dermatitis (AD) has been associated with increased risk of food allergy (FA), this association is not fully understood and the predictors of severe FA are not clear. In a review of 18 population-controlled studies, the rate of food sensitization was up to 6 times higher in patients with AD versus normal controls.1 A recent study identified a potential physiologic mechanism by demonstrating increased skin barrier dysfunction, measured by increased transepidermal water loss and reduced skin filaggrin levels, in patients with AD and FA.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Alpha-gal allergy is associated with immunoglobulin E (IgE) antibodies to galactose- α-1,3-galactose (alpha-gal), a carbohydrate found in beef, pork, and lamb. First described in the adult population in 2009 by Commins et al., this syndrome is associated with delayed anaphylaxis, angioedema, and urticaria with symptom onset 3 to 6 hours after eating red meat.1,2,3 Bites from ticks, namely the Lone Star Tick (Amblyomma americanum) in the United States, are associated with production of IgE antibodies to alpha-gal, resulting in an immune system primed to react to foods containing the antigen in patients who previously ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Abstract Anaphylaxis is an acute, potentially life-threatening systemic hypersensitivity reaction. Classically, anaphylaxis is an immunoglobulin (Ig) E-mediated reaction; however, IgG or immune complex complement-related immunologic reactions that lead to degranulation of mast cells can also cause anaphylaxis. Food allergy is the most common cause of anaphylaxis, followed by drugs. Patients with anaphylaxis commonly present with symptoms involving skin or mucous membranes, followed by respiratory and gastrointestinal symptoms. Epinephrine is the drug of choice for treating anaphylaxis. Patients and caregivers shou...
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Pediatr Clin North Am Source Type: research
We have identified peroxidase I as a causative allergen for wheat-dependent exercise-induced anaphylaxis developed as pollen food allergy syndrome(PFAS-WDEIA) due to cross-reaction between wheat proteins and grass pollen allergens. The purpose of this study is to establish peroxidase I-specific IgE test and test its sensitivity and specificity to identify PFAS-WDEIA. Serum were obtained from 6 patients with PFAS-WDEIA, 18 patients with conventional WDEIA, 11 patients with hydrolyzed wheat protein allergy, 11 patients with hay fever, and 22 patients with red meat/crustacean allergy.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Abstract Over the past few decades, an increase in the prevalence of asthma and food allergy has been observed in the pediatric population. In infants, food sensitization, particularly to egg, has increased the risk of developing allergic asthma. This is even more likely if sensitization to food allergens occurs early within the first few years of life. It is indeed known that both diseases may be present simultaneously in the pediatric population, but coexistence may negatively influence the severity of both conditions by increasing the risk of life-threatening asthmatic episodes as well as food-related anaphylax...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
Abstract Childhood food allergies are a growing public health problem. Once the offending food allergens have been identified, a strict elimination diet is necessary in treatment or prevention of most of the allergic reactions. Accidental food ingestion can lead to severe anaphylaxis. Food- derived substances can be used in medications at various stages of the manufacturing process. In this review, the possible roles of medications which may contain egg, red meat, gelatin, and fish allergens on allergic reactions in children with food allergy were evaluated. PMID: 31430986 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized allergies health onetime syndication Source Type: news
Anaphylaxis is an acute, potentially life-threatening systemic hypersensitivity reaction. Classically, anaphylaxis is an immunoglobulin (Ig) E –mediated reaction; however, IgG or immune complex complement-related immunologic reactions that lead to degranulation of mast cells can also cause anaphylaxis. Food allergy is the most common cause of anaphylaxis, followed by drugs. Patients with anaphylaxis commonly present with symptoms involvi ng skin or mucous membranes, followed by respiratory and gastrointestinal symptoms. Epinephrine is the drug of choice for treating anaphylaxis. Patients and caregivers should be educ...
Source: Pediatric Clinics of North America - Category: Pediatrics Authors: Source Type: research
Food allergy is an immune-mediated disease and must be differentiated from other adverse effects related to food that are non –immune mediated. Symptoms of immunoglobulin (Ig) E–mediated allergy can range from mild to severe, and life-threatening anaphylaxis may occur. Current recommended strategies for diagnosis include the use of skin prick tests, allergen-specific serum IgE, and/or oral food challenges. Management e ntails allergen avoidance and appropriate treatment of allergic reactions should accidental ingestions occur. Treatment approaches under investigation include immunotherapy as well as biologics a...
Source: Pediatric Clinics of North America - Category: Pediatrics Authors: Source Type: research
Abstract Childhood allergy is common, and increasing. Many children are incorrectly labeled as having allergy or adverse drug reactions. This can pose a dilemma for anesthetists and lead to a change in practice or drug selection. We review the pathophysiology of hypersensitivity reactions and the implications for anesthesia of food allergy, atopy, and family history of allergy in children. The epidemiology of anaphylaxis is discussed. We discuss the common triggers of perioperative anaphylaxis in children and explore emerging triggers including chlorhexidine and sugammadex. Accurate data on pediatric perioperative...
Source: Paediatric Anaesthesia - Category: Anesthesiology Authors: Tags: Paediatr Anaesth Source Type: research
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