Longitudinal progression of aspirin ‐exacerbated respiratory disease: analysis of a national insurance claims database

ConclusionUpper and lower airway disease is often initially recognized in patients with AERD, whereas drug sensitivity presents month to years later. This delay may be due to the pathophysiology of AERD and disease progression or due to practice patterns in diagnostic testing and coding. Further work is warranted to identify these patients at early stages in their disease progression.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Chronic rhinosinusitis is a long-lasting medical condition, usually caused by infection or exposure to irritants, such as allergies, that affects one in seven American adults. Symptoms include nasal obstruction, nasal congestion, nasal drainage, loss of smell and taste, and facial pain and pressure. Some people with chronic rhinosinusitis also develop additional symptoms, such as asthma and nasal polyps, that are exacerbated by underlying allergies. A nasal polyp is a noncancerous tumor that grows from the lining of the nose or sinuses and affects the drainage system of the sinuses. While chronic rhinosinusitis is not a li...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Cold and Flu Drugs and Supplements Ear, nose, and throat Health Source Type: blogs
Publication date: Available online 4 September 2019Source: American Journal of OtolaryngologyAuthor(s): Rosati Davide, Rosato Chiara, Pagliuca Giulio, Cerbelli Bruna, Della Rocca Carlo, Di Cristofano Claudio, Martellucci Salvatore, Gallo AndreaAbstractBackgroundIn last years, many attempts were made to recognize chronic rhinosinusitis with nasal polyps (CRSwNP) phenotypes focusing on identifying relevant key pathogenic molecules. Polyps recurrence rate ranges from 4% to 60%, so it's clear that not all clinical and immunologic factors associated with recurrence are known.ObjectiveWe investigate the inflammatory profile in p...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: September–October 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 7Author(s): Claus Bachert, Peter W. Hellings, Joaquim Mullol, Robert M. Naclerio, Jingdong Chao, Nikhil Amin, Annette Grabher, Brian N. Swanson, Jennifer D. Hamilton, Sophie Guillonneau, Christine Taniou, Donghui Zhang, Gianluca Pirozzi, Neil M.H. Graham, Heribert Staudinger, Leda P. Mannent, Asif Khan
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
The incidence of chronic rhinosinusitis with nasal polyps has recently increased in Japan and other East Asian countries, and this disease is called eosinophilic chronic sinusitis (ECRS) in Japan. ECRS usually...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Case report Source Type: research
AbstractPurpose of ReviewChronic rhinosinusitis and nasal polyps (CRSwNP) is a common condition that significantly affects patients ’ life. This work aims to provide an up-to-date overview of CRSwNP in older adults, focusing on its aging-related clinical presentations, pathophysiology, and comorbidity associations including asthma.Recent FindingsRecent large population-based studies using nasal endoscopy have shown that CRSwNP is a mostly late-onset disease. Age-related changes in physiologic functions, including nasal epithelial barrier dysfunction, may underlie the incidence and different clinical presentations of ...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
A 21-year-old man with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and comorbid asthma the last ten years was referred for allergy evaluation. The diagnosis of CRSwNP was based on the patient ’s symptomatology (nasal congestion, atypical facial pain, hyposmia/anosmia), nasal endoscopy, and the objective evidence of mucosal inflammation (complete opacification of the paranasal sinuses on CT-scan that revealed marked mucosal thickening with partial opacification of right maxillary sinus, near complete opacification of left maxillary sinus, and complete opacification of right and left frontal and anterior et...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Challenging Clinical Cases Source Type: research
ConclusionsPrognosis in patients with CRSwNP was inferior to that in patients with CRSsNP. Asthma was the only factor that increased the chance of recurrence in patients with either CRSsNP or CRSwNP.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: Collection of nasal secretions on the filter paper is a practical and non-invasive method for in-depth study of nasal proteomics. Our proteomic signatures also support that Asian NPs could be characterized as non-eosinophilic inflammation features. Therefore, the proteomic profiling of nasal secretions from CRS patients may enhance our understanding of CRS endotypes. PMID: 31332980 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
CONCLUSIONS: Our results suggest that Th17/Th1-associated mediators and BAFF may play a role and be a potential therapeutic target in refractory CRSwNP. Additionally, eosinophilic markers and autoantibodies may contribute to refractoriness in asthmatic rNP. PMID: 31332978 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Aspirin-exacerbated respiratory disease (AERD) is a syndrome characterized by asthma that is often severe with progressive airway remodeling, the presence of eosinophilic chronic sinusitis with nasal polyp (CRSwNP) formation, and intolerance to aspirin and other non-selective cyclooxygenase 1 (COX-1) inhibitors.1 The prevalence of AERD in the general population is 1% which increases to 7% amongst those with asthma. In the most severe cases, ingestion of aspirin can trigger systemic reactions and even death.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research
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