Viruses, Vol. 11, Pages 780: Pulmonary Involvement during the Ebola Virus Disease

Viruses, Vol. 11, Pages 780: Pulmonary Involvement during the Ebola Virus Disease Viruses doi: 10.3390/v11090780 Authors: Eleonora Lalle Mirella Biava Emanuele Nicastri Francesca Colavita Antonino Di Caro Francesco Vairo Simone Lanini Concetta Castilletti Martin Langer Alimuddin Zumla Gary Kobinger Maria R. Capobianchi Giuseppe Ippolito Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013–2016 Ebola outbreak.
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research

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Source: Centers for Disease Control and Prevention (CDC). Published: 9/5/2019. This one-hour, 29-minute lecture, part of the Centers for Disease Control and Prevention (CDC) Office of Science “We Were There” series, details how disease detectives discovered the Ebola virus in 1976 in Zaire (now the Democratic Republic of the Congo), and how the understanding of it has grown with subsequent outbreaks over the past 40 years. Samples of the unidentified disease in that outbreak yielded alarming images of a filovirus resembling Marburg, but serology testing at the CDC showed a new virus, later named Ebola. (Video or Multimedia)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 29 August 2019Source: Antiviral ResearchAuthor(s): Antonello Pessi, Sandra L. Bixler, Veronica Soloveva, Sheli Radoshitzky, Cary Retterer, Tara Kenny, Rouzbeh Zamani, Glenn Gomba, Dima Gharabeih, Jay Wells, Kelly S. Wetzel, Travis K. Warren, Ginger Donnelly, Sean A. Van Tongeren, Jesse Steffens, Allen J. Duplantier, Christopher D. Kane, Pascale Vicat, Valerie Couturier, Kent E. KesterAbstractThe Filoviridae family consists of five ebolavirus species, Ebola (EBOV), Sudan (SUDV), Bundibugyo virus (BDBV), Reston (RESTV), and Taï Forest (TAFV) viruses, and a Marburgvirus species, with Ma...
Source: Antiviral Therapy - Category: Virology Source Type: research
S Abstract The Filoviridae family consists of five ebolavirus species, Ebola (EBOV), Sudan (SUDV), Bundibugyo virus (BDBV), Reston (RESTV), and Taï Forest (TAFV) viruses, and a Marburgvirus species, with Marburg (MARV) and Ravn (RAVV) viruses. Ebola virus (EBOV) has emerged as a significant public health concern since the 2013-2016 Ebola Virus Disease outbreak in Western Africa. Currently, there are no therapeutics approved and the need for Ebola-specific therapeutics remains a gap. In search for anti-Ebola therapies we tested the idea of using inhibitory properties of peptides corresponding to the C-terminal...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Publication date: Available online 6 August 2019Source: Journal of Theoretical BiologyAuthor(s): Chengyuan Wu, Shiquan Ren, Jie Wu, Kelin XiaAbstractWe introduce an alignment-free method, the Magnus Representation, to analyze genome sequences. The Magnus Representation captures higher-order information in genome sequences. We combine our approach with the idea of k-mers to define an effectively computable Mean Magnus Vector. We perform phylogenetic analysis on three datasets: mosquito-borne viruses, filoviruses, and bacterial genomes. Our results on ebolaviruses are consistent with previous phylogenetic analyses, and confi...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
sen van Vuren Filovirus serological diagnosis and epidemiological investigations are hampered due to the unavailability of validated immunoassays. Diagnostic performance of three indirect enzyme-linked immunosorbent assays (I-ELISA) was evaluated for the detection of IgG antibody to Ebola virus (EBOV) in human sera. One I-ELISA was based on a whole EBOV antigen (WAg) and two utilized recombinant nucleocapsid (NP) and glycoproteins (GP), respectively. Validation data sets derived from individual sera collected in South Africa (SA), representing an EBOV non-endemic country, and from sera collected during an Ebola disease...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
by Brien K. Haun, Varney Kamara, Abigail S. Dweh, Kianalei Garalde-Machida, Saymajunkon S. E. Forkay, Melissa Takaaze, Madhuri Namekar, Teri Ann S. Wong, Ayesha E. R. Bell-Gam Woto, Peter Humphreys, Ophelia I. Weeks, Mosoka P. Fallah, John M. Berestecky, Vivek R. Nerurkar, Axel T. Lehrer Filoviruses such as Ebola virus (EBOV) cause outbreaks of viral hemorrhagic fevers for which no FDA-approved vaccines or drugs are available. The 2014–2016 EBOV outbreak in West Africa infected approximately 30,000 people, killing more than 11,000 and affecting thousands more in areas still suff ering from the effects of civil wars....
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract rVSVΔG-ZEBOV-GP vaccine is a live recombinant (r) vesicular stomatitis virus (VSV), where the VSV G protein is replaced with the Zaire Ebola virus (ZEBOV) glycoprotein (GP). For vaccine immunogenicity testing, clinical trial sera collected during an active ZEBOV outbreak underwent gamma irradiation (GI) before testing in biosafety level 2 laboratories to inactivate possible wild-type ZEBOV. Before irradiating pivotal trial samples, two independent studies evaluated the impact of GI (50 kGy) on binding ZEBOV-GP (ELISA) antibodies against rVSVΔG-ZEBOV-GP, using sera from a North American phase 1...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Discussion Genome comparison of over 1,230 non-redundant, high quality EBOV full-length sequences within the Zaire lineage revealed both conserved and highly variable regions (Figure 1). The latter were concentrated in non-coding sequences, which were also more AT-rich than coding sequences, an observation that has also been made for other virus species, for instance Hepatitis B virus (González et al., 2018). The AT-content of coding sequences was most likely lower due to codon constraints, though we observe that the gene for RNA polymerase is richer in AT than the other EBOV genes. The analysis further identified ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: April 2019Source: Current Opinion in Virology, Volume 35Author(s): Megan R Edwards, Christopher F BaslerThe filovirus family includes some of the deadliest viruses known, including Ebola virus and Marburg virus. These viruses cause periodic outbreaks of severe disease that can be spread from person to person, making the filoviruses important public health threats. There remains a need for approved drugs that target all or most members of this virus family. Small molecule inhibitors that target conserved functions hold promise as pan-filovirus therapeutics. To date, compounds that effectively target virus ...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Authors: Tembo J, Simulundu E, Changula K, Handley D, Gilbert M, Chilufya M, Asogun D, Ansumana R, Kapata N, Ntoumi F, Ippolito G, Zumla A, Bates M Abstract INTRODUCTION: Viruses from the family Filoviridae can cause viral haemorrhagic fevers (VHFs), including Ebola virus disease (EVD) and Marburg virus disease (MVD). The 2014-16 outbreak of EVD in West Africa resulted in 11,308 deaths, representing a case fatality rate of 39.5%. During the outbreak, only 60% of patients were laboratory confirmed and global health authorities have identified the need for accurate and readily deployable molecular diagnostics as an i...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
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