ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells

HER3/ErbB3 receptor deletion or blockade leads to tumor cell apoptosis, whereas its overexpression confers anti-cancer drug resistance through upregulation of protective mechanisms against apoptosis. We produc...
Source: Cell Communication and Signaling - Category: Molecular Biology Authors: Tags: Research Source Type: research

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Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
In conclusion, ITCH may downregulate GLUT1 and suppresses glucose uptake in melanoma to inhibit cancer cell proliferation. PMID: 31403357 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Itchy armpits may occasionally be due to cancer, although there are many more likely causes. Infections and underlying skin conditions are some other reasons. Learn more here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
If you’re the type who dons new duds without washing them first, there’s a chance you may pay a price for it a few days later. A red, itchy, painful price. Allergic contact dermatitis is an immune system-related reaction to an allergen that has come into contact with your skin. It causes a delayed reaction: a rash that appears a few days after exposure, and then can last for weeks. “When we see allergic contact dermatitis from clothing, it’s usually from disperse dyes,” says Dr. Susan Nedorost, a professor of dermatology at Case Western Reserve University and director of the dermatitis program...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized chemicals Environmental Health Lifestyle Source Type: news
This study aimed to explore the correlation of circular RNA itchy E3 ubiquitin protein ligase (circ-ITCH) with pathological features as well as its predictive value on prognosis in prostate cancer patients. METHODS: Three hundred and twenty-four patients with prostate cancer underwent radical prostatectomy were consecutively included in this retrospective study, and patients' specimens of tumor as well as paired adjacent tissues were collected for detection of circ-ITCH expression. Patients' baseline characteristics and survival data were obtained from follow-up records, and correlation of circ-ITCH with patients' path...
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
A South San Francisco startup led by veterans of biotech stalwart Genentech Inc. and its parent company Roche wants to raise $86.25 million in an initial public offering. RAPT Therapeutics Inc. — known until May as FLX Bio Inc. — expects to use the IPO booty to fund development of cancer-fighting FLX-475 through results of an ongoing Phase I/II clinical trial, fund an early-stage safety trial of RPT-193 in the itchy skin condition known as atopic dermatitis an d develop other drug candidates,…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
EXCLUSIVE: Chris Davey, 59, of Bristol, visited his GP about his change in stools and itchy skin. He was one of the very few to be diagnosed with pancreatic cancer early and receive surgery.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionMM survivors experience chronic treatment toxicities and frequently report psychological concerns.Implications for Cancer SurvivorsSurvivors may benefit from discussions regarding long-term toxicities and tailored psychological supports.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
CONCLUSION: We present the case of allergic contact dermatitis (ACD) due to hypersensitivity to fentanyl with good tolerance to buprenorphine. Positive PT in this patient suggests a type IV hypersensitivity mechanism. Allergic reactions to opioids are frequently immediate, but delayed reactions could appear, especially when the drug is administered topically. PMID: 31131754 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
The “acute” itch-scratch reflex, considered a protective and evolutionarily conserved mechanism can become dysfunctional in the setting of many chronic skin diseases, resulting in chronic itch (Mollanazar et al. 2016; Talwalkar et al. 2003; Steinhoff et al. 2018). The resultant debilitating itch-scr atch cycle can occur in inflammatory skin diseases, neurological diseases (Meng et al. 2018; Steinhoff et al. 2012) and systemic conditions such as cancer, diabetes, renal or hepatic disorders (Matterne et al.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
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