Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota.

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota. Alzheimers Dement. 2019 Aug 13;: Authors: Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q, Tang H, Chen S Abstract OBJECTIVE: Gut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia. BACKGROUND: AD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, whereas the microbiota in MCI before the onset of dementia has not been discovered and characterized in humans. NEW/UPDATED HYPOTHESIS: We hypothesize that the dysbiosis happens in the MCI stage. Patients with AD and MCI have decreased microbial diversity, and changes in gut microbiota could be detected for early detection of AD. In our preliminary study, we identified differences between AD and normal controls in 11 genera from the feces and 11 genera from the blood. No difference in genera between AD and MCI was detected. Using the diagnostic model from fecal samples with all different genera input, 93% (28 in 30) of patients with MCI could be identified correctly. MAJOR CHALLENGES FOR THE HYPOTHESIS: The diagnosis of MCI and AD in the study was based on symptoms and neuroimaging, and AD biomarkers should be included ...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research

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Publication date: Available online 18 August 2019Source: Alzheimer's &DementiaAuthor(s): Binyin Li, Yixi He, Jianfang Ma, Pei Huang, Juanjuan Du, Li Cao, Yan Wang, Qin Xiao, Huidong Tang, Shengdi ChenAbstractObjectiveGut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia.BackgroundAD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, w...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Sandip T. Auti and Yogesh A. Kulkarni* Shobhaben Pratapbhai Patel School of Pharmacy &Technology Management, SVKM's NMIMS, Mumbai, India Acetylcholinesterase (AChE) is an enzyme involved in the progression of Alzheimer's disease (AD). Cardamom oil (CO) has been reported to have acetylcholinesterase inhibitory, antioxidant and anti-anxiety effects. Hence, we studied the effect of cardamom oil in aluminum chloride induced neurotoxicity in rats. AD like symptoms were induced in Wistar rats with aluminum chloride (100 mg/kg, p.o.). Cardamom oil was administered concomitantly by oral route at doses...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Olena Lykhmus1, Lyudmyla Koval1, Larysa Voytenko1, Kateryna Uspenska1, Serhiy Komisarenko1, Olena Deryabina2, Nadia Shuvalova2, Vitalii Kordium2,3, Alina Ustymenko2, Vitalii Kyryk2 and Maryna Skok1* 1Laboratory of Cell Receptors Immunology, Palladin Institute of Biochemistry NAS, Kyiv, Ukraine 2Department of Gene Technologies, State Institute of Genetic and Regenerative Medicine NAMS, Kyiv, Ukraine 3Department of Cell Regulatory Mechanisms, Institute of Molecular Biology and Genetics NAS, Kyiv, Ukraine Neuroinflammation is regarded as one of the pathogenic factors of Alzheimer disease (AD). Previously, we showe...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
  Answer: No—unless you do it for more than a few months. After a few months, the upfront metabolic and weight benefits will begin to reverse and new health problems arise. We know this with confidence. I raise this question once again because more and more people are coming to me reporting problems. It may take months, even years, but the long-term consequences can be quite serious. Achieving ketosis by engaging in a very low-carbohydrate, high-fat lifestyle is—without a doubt—an effective means of losing weight, breaking insulin and leptin resistance, reversing type 2 diabetes and fatty liver, redu...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: ketones bowel flora ketogenic ketotic undoctored wheat belly Source Type: blogs
DiscussionIn vitro phagocytosis of hPSC monocytes and tMGs was not affected by the TREM2+/R47H mutation but was significantly impaired in TREM2+/− and TREM2−/− progeny.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
This study shows that some genetic changes linked to cancer are present in surprisingly large numbers of normal cells. We still have a long way to go to fully understand the implications of these new findings, but as cancer researchers, we can't underestimate the importance of studying healthy tissue." Early Onset of Menopause Correlates with Shorter Life Expectancy https://www.fightaging.org/archives/2018/10/early-onset-of-menopause-correlates-with-shorter-life-expectancy/ Aging is a phenomenon affecting all organs and systems throughout the body, driven by rising levels of molecular damage. The v...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
When a UTI goes undetected in an Alzheimer's patient they can become mean, delusional, dull, disoriented or worse. Undetected UTIs are common in Alzheimer's and dementia patients.Yes, there is such a thing as asilent urinary tractinfection.Silent means no clear cut sign of physical pain, no burning sensation, and no discernible odor.The Connection Between UTI and Worsening DementiaBy Bob DeMarcoAlzheimer's Reading RoomSubscribe to the Alzheimer's Reading - This is a Free Service - Join NowThere arediscernible symptoms of a UTI indementia patients, but the symptoms arerarely connected to UTI by caregivers. This is especiall...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's dementia symptoms alzheimer's urinary tract infection dementia care elder care health help with dementia care memory care memory care facility nursing home uti alzheimers Source Type: blogs
Up until the first half of the twentieth century, large-scale health disasters were mostly due to natural causes (earthquakes, volcanoes, hurricanes, etc.) or infections (e.g., smallpox, influenza epidemics, cholera). But something peculiar happened as we entered the second half of the century: Health disasters due to natural causes became dwarfed by large-scale health disasters that are man-made. Here’s a list of the Six Worst U.S. Health Disasters of the Last 50 Years, mostly man-made phenomena that have exacted huge tolls: widespread disease, premature death, poorly managed (though nonetheless highly profitable fo...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle autoimmune gluten grain-free grains Inflammation low-carb Weight Loss Source Type: blogs
In conclusion, CAVD is highly prevalent. Long understood as a passive process, it is now known to be complex and one which involves pathophysiological mechanisms similar to those of atherosclerosis. Understanding these mechanisms could help to establish new therapeutic targets that might allow us to halt or at least slow down the progression of the disease. Early Steps in the Tissue Engineering of Intervertebral Discs https://www.fightaging.org/archives/2017/08/early-steps-in-the-tissue-engineering-of-intervertebral-discs/ In this paper, researchers report on progress towards the manufacture of interver...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men. Citation: Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro A III, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. 2017. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: the VA Normative Aging Study. Environ Health Perspect 125:76–81; http://dx.doi.org/10.1289/EHP241 Address correspondence to E. Colicino, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave., Building 1, Room G03,...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Articles January 2017 Source Type: research
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