Palladacycle promoted asymmetric hydrophosphination of α,β-Unsaturated sulfonyl fluorides

Publication date: Available online 22 August 2019Source: Journal of Organometallic ChemistryAuthor(s): Xi-Rui Li, Houguang Jeremy Chen, Weifan Wang, Mengtao Ma, Yu Chen, Li Yongxin, Sumod A. Pullarkat, Pak-Hing LeungAbstractThe first example of an enantioselective hydrophosphination reaction of ethenesulfonyl fluoride derivatives catalyzed by a phosphapalladacycle afforded chiral sulfonyl fluoride-derived phosphines in quantitative yields and enantioselectivities of up to 93% ee. Investigations revealed the importance of adjacent vacant sites within the active metal center for intramolecular nucleophilic attack to provide the functionalized phosphine.Graphical abstract

Source: Journal of Organometallic Chemistry - August 24, 2019 Category: Chemistry Source Type: research