The Testosterone Trap

Should the Modern Man Be Taking Testosterone? Is It Low T? .com By now you've likely seen the commercials. Fit-looking middle-age men telling you how they put on weight, had less energy, and were no longer the sexual tigers they were in their twenties -- until, that is, they started rubbing testosterone gel on their shoulder, upper arm, or abdomen. Now they feel more like the men they used to be. The commercials don't mention a 2009 study in the New England Journal of Medicine wherein a group of men on testosterone replacement therapy had more than four times the number of cardiovascular problems -- so many that the study had to be halted. They also don't make clear how risky exposure to testosterone gel is for others -- female partners, children, even pets. The gel is actually notorious for transferring to others. It can cause excess hair to grow on women's faces and arms, deepen their voices, interrupt menstruation, and make them anxious and irritable. In children, exposure to testosterone gels and creams can cause premature puberty and aggression. And in pets, it can cause aggressive behavior and enlargement of the genitalia. Commercials do mention other potential side-effects for the male user, calling them "rare," including swollen and painful breasts, blood clots in the legs, increased risk for prostate cancer, problems breathing during sleep (sleep apnea), change in the size and shape of the testicles, and a low sperm count. But you're not supposed to ...
Source: PharmaGossip - Category: Pharma Commentators Authors: Source Type: blogs

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Source: AARP.org News - Category: American Health Source Type: news
Publication date: September 2018Source: Nano Energy, Volume 51Author(s): Jun Li, Lei Kang, Yanhao Yu, Yin Long, Justin J. Jeffery, Weibo Cai, Xudong WangAbstractImplantable nanogenerator (i-NG) has shown great promises for enabling self-powered implantable medical devices (IMDs). One essential requirement for practical i-NG applications is its long-term bio-compatibility and bio-safety. This paper presents a systematic study of polydimethylsiloxane (PDMS) and PDMS/Parylene-C packaged polyvinylidene fluoride (PVDF) NGs implanted inside female ICR (Institute of Cancer Research) mice for up to six months. The PVDF NG had a st...
Source: Nano Energy - Category: Nanotechnology Source Type: research
Publication date: Available online 21 July 2018Source: Seminars in Cell &Developmental BiologyAuthor(s): Jiayun Hou, Xiangdong WangAbstractPolycomb group proteins (PcG) play important roles in the maintenance of DNA sequencing and multi-dimensional organization of genome. The main PcG complexes are consisted of Polycomb repressive complex 1 and 2, of which the diversity is dependent upon target gene sequences and functions. The present review initially explores the mechanism-based relationship and functional roles of PcG proteins in the interplay between epithelial mesenchymal transition (EMT) and chromatin dynamics in...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
CONCLUSION: Many senior obstetrics and gynaecology residents in Canada lack knowledge around POI, and most indicate need for further exposure to POI during residency training. We identified an opportunity for improved POI curricula. PMID: 30025870 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Publication date: Available online 21 July 2018Source: NeuroImageAuthor(s): Meredith L. Wallace, Layla Banihashemi, Christopher O'Donnell, Vishwajit L. Nimgaonkar, Chowdari Kodavali, Rebecca McNamee, Anne GermainAbstractComparing the neural outcomes of two randomized experimental groups is a primary aim of many functional neuroimaging studies. However, between-group effects can be obscured by heterogeneity in neural responses. Optimal Combined Moderator (OCM) approaches have previously been used to clarify heterogeneity in clinical outcomes following treatment randomization. We show that OCMs can also be used to clarify he...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 21 July 2018Source: Obesity Research &Clinical PracticeAuthor(s): George L. WehbyAbstractGenetic studies of BMI have largely focused on how average BMI changes with SNPs or polygenic risk scores (PRS). We examine the effects of a BMI PRS on changes in BMI percentiles, range, and skewness using quantile regression and US nationally representative data from the Health and Retirement Survey. We find that the BMI PRS is associated with meaningfully larger weight increases at higher than lower BMI percentiles; the 90th BMI percentile increases by 4.7 units with a one SD increase in the PRS...
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
DIABETES type 2 symptoms are triggered when there are problems with blood sugar levels. This is because of problems with the hormone insulin, which affects cells ’ ability to take in sugar. It is possible to develop ‘borderline’ diabetes, or pre diabetes, before the condition. Watch out for these symptoms.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study examined the prevalence and associated factors of risky sexual behaviours among 1648 school-going adolescents using the 2012 Ghana Global School-based Student Health Survey. Our findings showed 33.5% of the participants had ever had sex 32.5% had multiple sexual partners and only 26.2% reported using condom during their last sexual intercourse. Being male, older age, anxiety, loneliness, suicidal ideation, being bullied, food insecurity (hunger), current alcohol and marijuana use were significant risk factors for being sexually experienced, multiple partners, but not condom use. Parental knowledge of activity wa...
Source: Journal of Adolescence - Category: Child Development Source Type: research
In this study, we found that overexpression of nicotinamide nucleotide transhydrogenase (NNT) was associated with shorter overall and disease free survival in gastric cancer. The NNT is considered a key antioxidative enzyme based on its ability to regenerate NADPH from NADH. Knockdown of NNT caused significantly NADPH reduction, induced high levels of ROS and significant cell apoptosis under oxidative stress conditions such as glucose deprival and anoikis. In vivo experiments showed that NNT promoted tumor growth, lung metastasis and peritoneal dissemination of gastric cancer. Moreover, intratumoral injection of NNT siRNA ...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 21 July 2018Source: Chemico-Biological InteractionsAuthor(s): Bharath Kumar VelmuruganAbstractThe psychoactive properties of cannabinoids are well known and there has been a continuous controversy regarding the usage of these compounds for therapeutic purposes all over the world. Their use for medical and research purposes are restricted in various countries. However, their utility as medications should not be overshadowed by their negative physiological activities. This review article is focused on the therapeutic potential and applications of phytocannabinoids and endocannabinoids. It h...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
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