Replicated methylation changes associated with eczema herpeticum and allergic response
Although epigenetic mechanisms are important risk factors for allergic disease, few studies have evaluated DNA methylation differences associated with atopic dermatitis (AD), and none has focused on AD with ec...
Authors: von Csiky-Sessoms S Abstract A 42-year-old male with skin type I and a history of rosacea and eczema presented with crusting, erythema, and pustules distributed on the left oral commissure. Angular cheilitis was diagnosed and regular petrolatum use recommended until resolution of the lesion. Eight days later, with no improvement in symptoms, fungal and bacterial cultures were performed which resulted in the growth of cutibacterium acnes, a variant of p. acnes. PMID: 31524997 [PubMed - in process]
This article summarizes the most important treatment modalities based on case reports and series, clinical studies, guidelines and expert recommendations. PMID: 31515578 [PubMed - as supplied by publisher]
Authors: Mahler V, Dickel H Abstract The head and hands are the two most common locations for allergic contact dermatitis manifestation. In hand eczema, contact with a contact allergen is a frequent (co-)factor in the triggering and maintenance of eczema. For all hand eczemas lasting longer than 3 months, an allergological examination by means of patch testing is recommended. In patients with allergic contact dermatitis of the hands, nickel, MCI/MI, fragrance mix I, cobalt, thiuram mix, Balsam of Peru, chromium and fragrance mix II have been described in a multicenter European study as...
CONCLUSION: The exact understanding of the individual pathogenesis in single hand eczema patients is essential in order to provide specific advice on allergen avoidance, skin protection and basic treatment and to initiate appropriate therapeutic measures. PMID: 31501971 [PubMed - as supplied by publisher]
Condition: Dermatitis, Atopic Intervention: Drug: BI 655130 Sponsor: Boehringer Ingelheim Not yet recruiting
CONCLUSIONS: Generalized prurigo nodularis is currently also considered as a rather common clinical pattern of adult AD. Dupilumab can be an efficacious treatment of this condition, especially in cases where history of atopy is recorded and conventional treatments are ineffective. PMID: 31517666 [PubMed - as supplied by publisher]
Condition: Dermatitis, Atopic Interventions: Drug: LY3471851; Drug: Placebo Sponsors: Eli Lilly and Company; Nektar Therapeutics Not yet recruiting