Assessment of Interstitial Lung Disease Using Lung Ultrasound Surface Wave Elastography: A Novel Technique With Clinicoradiologic Correlates

Purpose: Optimal strategies to detect early interstitial lung disease (ILD) are unknown. ILD is frequently subpleural in distribution and affects lung elasticity. Lung ultrasound surface wave elastography (LUSWE) is a noninvasive method of quantifying superficial lung tissue elastic properties. In LUWSE a handheld device applied at the intercostal space vibrates the chest at a set frequency, and the lung surface wave velocity is measured by an ultrasound probe 5 mm away in the same intercostal space. We explored LUWSE’s ability to detect ILD and correlated LUSWE velocity with physiological, quantitative, and visual radiologic features of subjects with known ILD and of healthy controls. Materials and Methods: Seventy-seven subjects with ILD, mostly caused by connective tissue disease, and 19 healthy controls were recruited. LUSWE was performed on all subjects in 3 intercostal lung regions bilaterally. Comparison of LUSWE velocities pulmonary function testing, visual assessment, and quantitative analysis of recent computed tomographic imaging with Computer-Aided Lung Informatics for Pathology Evaluation and Rating (CALIPER) software. Results: Sonographic velocities were higher in all lung regions for cases, with the greatest difference in the lateral lower lung. Median velocity in m/s was 5.84 versus 4.11 and 5.96 versus 4.27 (P
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Original Articles Source Type: research

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ObjectiveTo examine and quantify the sexual dimorphism in pathologic features manifested in the musculoskeletal and cardiopulmonary systems and incidence of mortality in the tumor necrosis factor –transgenic (TNF‐Tg; Tg3647 strain) mouse model of inflammatory erosive arthritis.MethodsKaplan ‐Meier survival estimates were determined in male and female Tg3647 mice and sex‐matched wild‐type (WT) littermate mice. Longitudinal and cross‐sectional pathologic outcomes in the musculoskeletal and cardiopulmonary systems were assessed via ultrasound, micro–computed tomography, grip str ength measurements, histo...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
AbstractLung ultrasound (LUS) correlates with chest high-resolution computed tomography (HRCT) findings in the diagnosis of interstitial lung disease (ILD) in systemic sclerosis (SSc). The aim of this study is to evaluate the predictive value of LUS in the progression of ILD. At baseline, forty-one SSc patients underwent HRCT, LUS for detection of B-lines, and pulmonary function test (PFTs). PFTs were performed also after 12  months to evaluate pulmonary function deterioration. In multiple regression analysis, positive correlation exists between the number of B-lines and HRCT score (r = 0.51,p 
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
CONCLUSION: In conclusion, in spite of a great deal of work supporting the potential role of LUS for the assessment of ILD-SSc too much remains to be done to validate its use as an outcome measure in ILD-SSc. PMID: 31263075 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
AbstractLung ultrasound (LUS) achieved an intriguing role in the management of pulmonary involvement in patients affected by connective tissues diseases (CTDs). Few studies have been performed to support its usefulness in the evaluation of the presence and the severity of interstitial lung disease (ILD), relating it to the information obtained with chest high-resolution computed tomography (HRCT). These results open up new fields of research in order to demonstrate the utility of LUS as screening tool to evaluate ILD in CTD. The aim of this review is to provide the “state of the art” of the role of LUS in the m...
Source: La Radiologia Medica - Category: Radiology Source Type: research
Lung diffusing capacity for nitric oxide may be of clinical value in systemic sclerosis because more sensitive to interstitial lung disease than standard lung diffusing capacity for carbon monoxide. AbstractA decreased lung diffusing capacity for carbon monoxide (DLCO) in systemic sclerosis (SSc) is considered to reflect losses of alveolar membrane diffusive conductance for CO (DMCO), due to interstitial lung disease, and/or pulmonary capillary blood volume (VC), due to vasculopathy. However, standard DLCO does not allow separate DMCO from VC. Lung diffusing capacity for nitric oxide (DLNO) is considered to be more sensiti...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
AbstractPurpose of the ReviewNovel imaging approaches, such as quantitative computed tomography (CT), magnetic resonance imaging (MRI), and molecular imaging, are being applied to interstitial lung diseases to provide prognostic, functional, and molecular information. Here, we review such imaging approaches and their applicability to systemic sclerosis-associated interstitial lung disease (SSc-ILD).Recent FindingsQuantitative CT can be used to quantify the radiographic response to SSc-ILD therapy. Due to advances in MRI sequence development, MRI can detect the presence of SSc-ILD with high accuracy. MRI can also be utilize...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
Conclusion: Significant differences of surface wave speed were found between ILD patients and healthy control subjects for both the lung and skin. Significance: LUSWE may be useful for assessing ILD and SSc and screening early stage patients.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Interstitial lung disease (ILD) is a common complication of connective tissue disease (CTD) and a leading cause of morbidity and mortality. There are various lung ultrasound (LUS) scoring systems with differen...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
ConclusionsWe find that TNF selectively drives early onset arthritis and cardiopulmonary pathologies in females. These results in the Tg3647 mouse identify it as a suitable model to better understand the mechanisms underlying sexual dimorphism and cardiopulmonary disease in the setting of inflammatory arthritis and other connective tissue diseases.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
Publication date: Available online 25 March 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Gabriela Gayer
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
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