Renal cell tumors with an entrapped papillary component: a collision with predilection for oncocytic tumors

AbstractRenal cell tumors with mixed morphology resembling multiple renal cell carcinoma (RCC) subtypes are generally regarded as unclassified RCC. However, occasionally, papillary adenoma or RCC appears admixed with a larger, different tumor histology. We retrieved 17 renal tumors containing a papillary adenoma or papillary RCC component admixed with another tumor histology and studied them with immunohistochemistry and fluorescence in situ hybridization (FISH). Larger tumors were oncocytomas (n = 10), chromophobe RCCs (n = 5), borderline oncocytic tumor (n = 1), and clear cell RCC (n = 1). The size of papillary component ranged from 1 to 34 mm. One tumor was an oncocytoma encircled by a cyst (2.0 cm) with papillary hyperplasia of the lining. The papillary lesions were diffusely cytokeratin 7 positive (17/17), in contrast to “host” tumors. Alpha-methylacyl-coA-racemase labeling was usually stronger in the papillary lesions (13/15). KIT was negative in all papillary lesions and the clear cell RCC and positive in 16/16 oncocytic or chromophobe tumors. Eight of 15 (53%) collision tumors had differing FISH results in the two components. A papillary renal cell prolifer ation within another tumor is an uncommon phenomenon with predilection for oncocytoma and chromophobe RCC, possibly related to their common entrapment of benign tubules. When supported by distinct morphology and immunohistochemistry in these two ...
Source: Virchows Archiv - Category: Pathology Source Type: research

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Dalton Trans., 2019, Advance Article DOI: 10.1039/C9DT03221E, PaperBiyun Sun, Madhu K. Sundaraneedi, Hannah M. Southam, Robert K. Poole, Ian F. Musgrave, F. Richard Keene, J. Grant Collins The non-linear polypyridylruthenium(II) complex (Rubb7-TNL) exhibited good antimicrobial activity, but surprisingly was also highly active against cancer cells. The results suggestRubb7-TNL may have potential as a new anticancer agent. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
[The Herald] Health and Child Care Ambassador, First Lady Auxillia Mnangagwa yesterday commended the National Aids Council of Zimbabwe for donating cervical cancer screening machines to the Ministry of Health and Child Care.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Xiao-tong Wang, Ru Fang, Sheng-bing Ye, Ru-song Zhang, Rui Li, Xuan Wang, Rong-hao Ji, Zhen-feng Lu, Heng-hui Ma, Xiao-jun Zhou, Qiu-yuan Xia, Qiu RaoAbstractAnaplastic lymphoma kinase (ALK)-rearranged renal cell carcinoma (RCC) is a novel entity of rare tumors with only 10 cases reported in the literature. Three RCC cases bearing VCL-ALK gene fusion were all young African American patients and associated with sickle cell trait notably. In contrast to the 3 reported cases, this neoplasm occurred in a middle-age woman (57...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsIL17RB predicts the prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In this study, we investigated the cytotoxic effect of cisplatin, a clinical chemotherapeutic for cervical cancer treatment, on parental and spheroid CVC cells and surveyed the effect of LncRNA on drug-resistance. We found that spheroid CVC cells showed much more resistant to cisplatin-induced cytotoxicity compared with parental CVC cells. Furthermore, cisplatin significantly induced apoptotic cell death, while it induced cell cycle arrest in G0/G1 phase at the same dose (10 μg/ml). We also found the significant expression of EGFR in spheroid instead of parental CVC cells. Interestingly, we revealed that protrudi...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Banita Thakur, Yashwant Kumar, Alka BhatiaAbstractBreast cancer is one of the major causes of cancer related deaths in women worldwide. A major factor responsible for treatment failure in breast cancer is the development of resistance to commonly used chemotherapeutic drugs leading to disease relapse. Several studies have shown dysregulation of molecular machinery of apoptosis, the major programmed cell death pathway in breast malignancies. Thus, there is an unmet need to search for an alternative cell death pathway whic...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 17 September 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Emily Han-Chung Hsiue, Pei-Lin Lee, Yung-Hsuan Chen, Chong-Jen Yu
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
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