Ruth Bader Ginsburg completes radiation therapy
Supreme Court Justice Ruth Bader Ginsburg has had another bout with cancer. The court announced that Ginsburg, 86, just completed three weeks of radiation treatment for a cancerous tumor on her pancreas. Ed O'Keefe reports.
Publication date: November 2019Source: Journal of Geriatric Oncology, Volume 10, Issue 6, Supplement 1Author(s): J. McDonald, E. Song, J. Frakes, M. Extermann, K. Latifi, D. Kim, M. Malafa, P. Hodul, J. Fleming, S.E. Hoffe
ConclusionsThis study demonstrates that intra-fraction targeting errors can be within 2mm while inter-fraction shifts from free-breathing spine to ABC breath-hold target can be as high as 8mm. Values that deviate significantly would need further investigation to rule out factors such as local progression, bowel gas or fiducial shift prior to treatment.
Conventionally fractionated (CF) radiation therapy (RT) has been associated with lymphopenia, leading to compromised overall survival (OS) in cancer patients. It currently remains unknown if stereotactic body ...
Conditions: Pancreatic Cancer; Pancreatic Adenocarcinoma Interventions: Radiation: Stereotactic Body Radiation Therapy (SBRT); Drug: FOLFIRINOX Sponsor: Indiana University Withdrawn
A Wilmot Cancer Institute research team reports that combining a type of radiation therapy with immunotherapy not only cures pancreatic cancer in mice, but appears to reprogram the immune system to create an “immune memory” in the same way that a vaccine keeps the flu away.
Abstract PURPOSE: To assess the effects of different beam starting phases on dosimetric variations in the clinical target volume (CTV) and organs at risk (OARs), and to identify the relationship between plan complexity and the dosimetric impact of interplay effects in volumetric-modulated arc therapy (VMAT) plans for pancreatic cancer. METHODS: Single and double full-arc VMAT plans were generated for 11 patients. A dose of 50.4 Gy in 28 fractions was prescribed to cover 50% of the planning target volume. Patient-specific Digital Imaging and Communications in Medicine-Radiation Therapy plan files were div...
Ionizing radiation (IR) can promote migration and invasion of cancer cells, but the basis for this phenomenon has not been fully elucidated. IR increases expression of glucose-regulated protein 78kDa (GRP78) on the surface of cancer cells (CS-GRP78), and this up-regulation is associated with more aggressive behavior, radioresistance, and recurrence of cancer. Here, using various biochemical and immunological methods, including flow cytometry, cell proliferation and migration assays, Rho activation and quantitative RT-PCR assays, we investigated the mechanism by which CS-GRP78 contributes to radioresistance in pancreatic du...
Evidence reviewed for radiation therapy in adjuvant, neoadjuvant, definitive, and palliative settings
AbstractPurposePancreatic ductal adenocarcinoma (PDAC) is the most common and lethal subtype of pancreatic cancer, with a 5-year survival rate of