What can we learn from fMRI capture of visual hallucinations in Parkinson ’s disease?

This study aimed to describe the patterns of brain functional changes when VH occ ur in PD patients. Nine PD patients were enrolled because of their frequent and chronic VH (> 10/day). Patients with severe cognitive decline (MMSE
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research

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oem B PMID: 31534023 [PubMed - as supplied by publisher]
Source: Practical Neurology - Category: Neurology Authors: Tags: Pract Neurol Source Type: research
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
A new study has found that lefties ’ brains could be associated with better verbal skills, among other talents. I always knew I was specialBeing a leftie has a genetic component, is linked to better verbal skills and is associated with a lower risk of Parkinson ’s disease, according toa new study published in the journal Brain. Unfortunately for Guardian readers, that ’s leftie in the handedness sense, not political. Fortunately for me, I’m both.The study is a fascinating one, using thousands of brain scans and hundreds of thousands of sequenced genomes to look for associations between genes, brains...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Genetics Source Type: news
This study investigated the effect of dextromethorphan (DXM) against Parkinson's disease (PD) in rats and explored the association between DXM dose and PD risk in elderly patients 65 years and older using a population-based database. The PD rat model (Sprague Dawley rats) was induced by injecting 6-hydroxydopamine (6-OHDA) into the unilateral medial forebrain bundle of the rat brain. DXM (20 mg/kg) was administered intraperitoneally twice daily from 7 days before the appearance of a 6-OHDA lesion to 28 days after the lesion appeared. The availability of dopamine transporter (DAT) and serotonin transporter (SERT) in the s...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
ConclusionQSM could be used for iron quantification of nigral and extranigral structures in all degenerative parkinsonisms and should be tested longitudinally in order to identify early microscopical changes.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusions: Deficits in static and dynamic balance control can be detected in PD patients using a novel MRI compatible balance simulator. This technique allows for functional neuroimaging to be combined with balance-relevant tasks, and provides a new means to create insights into the neural substrates contributing to postural instability in PD.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
(Acta Obstet Gynecol Scand. 2018;97:1025–1031) Ebstein’s anomaly is a rare congenital abnormality that is characterized by tricuspid regurgitation (TR) in association with apical displacement of the septal leaflet of the valve along with a small right ventricle. The severity of symptoms varies among patients with Ebstein’s anomaly and depends on factors such as right ventricular function, the severity of TR, and the presence of associated cardiac malformations. Atrial septal defect (ASD) and patent foramen ovale (PFO) have been reported in at least 50% of patients with Ebstein’s anomaly and Wolff-P...
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Mother, Fetus, Neonate Source Type: research
Conclusion. Frontal and striatal GM atrophy may contribute to the emergence of VH in DLB, which may be fostered by the more severe attention deficits. Striatal GM loss and executive dysfunction, instead, appeared to underlie VH in PD without dementia. PMID: 31422718 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
ConclusionU-net segmentation provided relatively high accuracy in the evaluation of the SNpc in NM-MRI and yielded diagnostic performance comparable to that of the established manual method.
Source: Neuroradiology - Category: Radiology Source Type: research
FRIDAY, Aug. 9, 2019 -- In patients with Parkinson disease (PD), vitamin D levels are significantly correlated with falls and some nonmotor symptoms, according to a study published online Aug. 6 in Acta Neurologica Scandinavia. Hui-Jun Zhang, M.D.,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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