Seroprevalence of H.  pylori Infection in a National Cohort of Veterans With Non-Cardia Gastric Adenocarcinoma

Conventional teaching is that Helicobacter pylori (HP) infection is required for the development of non-cardia gastric adenocarcinoma (NCGC) through a sequence of atrophic gastritis, intestinal metaplasia, dysplasia, and finally, cancer.1 –3 However, studies have not demonstrated a 100% rate of HP infection in gastric malignancy, hypothesized to be due to false negatives, gastric atrophy leading to apparent loss of infection, and inclusion of cardia, non-intestinal cancers.1–3
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Research Correspondence Source Type: research