Atrial fibrillation observed in a patient with esophageal cancer treated with fluorouracil

Publication date: Available online 23 August 2019Source: Journal of Cardiology CasesAuthor(s): Shohei Moriyama, Taku Yokoyama, Kei Irie, Mamoru Ito, Kenji Tsuchihashi, Mitsuhiro Fukata, Hitoshi Kusaba, Toru Maruyama, Koichi AkashiAbstractFluorouracil (5-FU), a commonly used anticancer agent, has potent cardiotoxicity that is mediated by vascular endothelial injury and vasospasm. Here, we report a patient demonstrating atrial fibrillation (AF), which was most likely induced by vasospasm mediated by 5-FU.A 69-year-old man presented with dysphagia and was diagnosed with advanced esophageal cancer. Frequent paroxysms of atrial fibrillation (AF) were observed during combination chemotherapy including 5-FU. AF was refractory to disopyramide, but was sensitive to antianginal agents (nicorandil and nitroglycerin transdermal patch). Coronary angiography performed within the chemotherapeutic period demonstrated moderate stenosis in the right coronary artery (RCA). Severe spasm at the proximal portion of the atrial branch in RCA was induced by provocation test using acetylcholine. Our case indicated that 5-FU predisposed vasospasm in RCA and the subsequent atrial ischemia may lead to AF.
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research

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ConclusionsThese results compare favourably to those reported by ECCG. Minimally Invasive esophagectomy can be the standard approach for surgical management of esophageal cancer. Introduction of the approach in each surgeon’s practice should be benchmarked to international standards.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Seesing MFJ, Borggreve AS, Ruurda JP, van Hillegersberg R Abstract Esophagectomy with en-bloc lymphadenectomy after neoadjuvant chemo(radio)therapy is the standard of care for resectable locally advanced esophageal cancer. Postoperative complications may have a significant impact on the duration of hospital stay and quality of life. Early recognition and treatment of complications may reduce failure to rescue rates and improve postoperative outcomes. New-onset atrial fibrillation (AF) after esophagectomy for cancer is frequently observed, and may be related to other postoperative complications. AF could fu...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Atrial fibrillation (AF) is a common complication after radical surgery of esophageal cancer. The aim of this study was to explore AF risk factors after radical surgery of esophageal carcinoma.
Source: Journal of Cardiothoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Research article Source Type: research
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This study was conducted from July 2013 to August 2016 and included 144 patients scheduled for thoracotomy under general anesthesia. We collected the patients’ demographic and perioperative medical data in our hospital. AF was diagnosed using electrocardiography (ECG), on the basis of the presence of characteristic ECG features of AF by one or more ECG leads for at least 30 seconds. Of the participants, 144 completed the study and 18 developed intraoperative AF. Higher percentages of subjects in the AF group than in the non-AF group had histories of chemotherapy (P = .014) and alcohol consumption (P = .034...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
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Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
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