Prediction of Adverse Pregnancy Outcomes in Women with Systemic Lupus Erythematosus
AbstractSystemic lupus erythematosus (SLE) is a chronic, autoimmune disease associated with major obstetrical complications such as gestational loss, preterm delivery, fetal growth restriction (FGR) and preeclampsia. Published literature is not consensual regarding the main risk factors for each of these outcomes. Our goal with this study was to determine the most important predictors for each of the main adverse pregnancy outcomes in this population. We conducted a retrospective cohort study of unifetal pregnancies of women with the diagnosis of SLE followed in our unit between January 1994 and December 2016. We excluded elective terminations of pregnancy and cases lost to follow-up and we analyzed 157 pregnancies (128 women). Multiple logistic regression models for the outcomes gestational loss, preterm delivery, fetal growth restriction, and preeclampsia were built. Two-sidedp-values of
An EMA panel recommended extending the indication for belimumab to children aged 5 years and older with systemic lupus erythematosus.International Approvals
Publication date: October 2019Source: Annals of Emergency Medicine, Volume 74, Issue 4Author(s): Lauren Westafer
Date: Wednesday, 10 30, 2019; Speaker: Pamela A. Guerrerio, MD, PhD, Chief, Food Allergy Research Unit, , Laboratory of Allergic Diseases, NIAID; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event
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Authors: Vasco-Blázquez Á, Avello-Taboada R, Sanllorente-Sebastián R, González-Barrera V, Arroyo-García B, Balzategi-Urrutia A Abstract PMID: 31527573 [PubMed - as supplied by publisher]
In this study, we hypothesized that preoperative pregabalin reduces inhaled isoflurane requirements. METHODS: We have investigated the effectiveness of preoperative oral pregabalin 150 mg in women undergoing elective open total abdominal hysterectomy under general anesthesia. A prospective, randomized, double-blind, controlled study was conducted in a university hospital. The study included 50 women (18-60 yrs.), ASA I or II, admitted for abdominal hysterectomy under general anesthesia. Exclusion criteria were allergy to pregabalin; calcium channel blockers, antiepileptic drugs, antidepressant drugs, any analgesics, se...
[FOOD ALLERGY]. Arerugi. 2019;68(8):893-903 Authors: Yanagida N PMID: 31534098 [PubMed - in process]
Authors: Ciccacci C, Latini A, Perricone C, Conigliaro P, Colafrancesco S, Ceccarelli F, Priori R, Conti F, Perricone R, Novelli G, Borgiani P Abstract Autoimmune diseases (AIDs) are complex diseases characterized by persistent or recurrent inflammation, alteration of immune response, and production of specific autoantibodies. It is known that different AIDs share several susceptibility genetic loci. Tumor necrosis factor alpha inducible protein 3 (TNFAIP3) encodes the ubiquitin-modifying enzyme A20, which downregulates inflammation by restricting NF-κB, a transcription factor that regulates expression of var...