Structural insights into coronavirus entry

Publication date: Available online 22 August 2019Source: Advances in Virus ResearchAuthor(s): M. Alejandra Tortorici, David VeeslerAbstractCoronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbreaks in humans with a fatality rate of 35%. SARS-CoV and MERS-CoV are zoonotic viruses that crossed the species barrier using bats/palm civets and dromedary camels, respectively. No specific treatments or vaccines have been approved against any of the six human coronaviruses, highlighting the need to investigate the principles governing viral entry and cross-species transmission as well as to prepare for zoonotic outbreaks which are likely to occur due to the large reservoir of CoVs found in mammals and birds. Here, we review our understanding of the infection mechanism used by coronaviruses derived from recent structural and biochemical studies.
Source: Advances in Virus Research - Category: Virology Source Type: research

Related Links:

South Korea has raised its animal disease alert to the highest level after discovering its first outbreak of deadly African swine fever at a pig farm in Paju, a town near its border with North Korea, the agriculture ministry said on Tuesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
California Gov. Gavin Newsom announces a crackdown on e-cigarettes and plans to launch a vaping awareness campaign amid U.S. lung illness outbreak.
Source: L.A. Times - Health - Category: Consumer Health News Authors: Source Type: news
California's governor on Monday ordered a public awareness campaign on health risks posed by a "youth epidemic" of vaping, but said he lacked authority to unilaterally ban flavored e-cigarettes that he said were deliberately marketed to children.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Adopting a more presumptive approach with parents may increase low vaccination uptake and completion, especially in younger adolescents.Medscape Medical News
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Pediatrics News Source Type: news
Purdue Pharma, a pharmaceutical company facing an onslaught of litigation for allegedly contributing to the opioid crisis, filed for bankruptcy on Sunday as part of a tentative, yet controversial settlement with state and local governments. Purdue is being sued in various courts over using allegedly deceptive marketing practices to promote its prescription painkiller OxyContin. One major federal case before an Ohio judge involves at least 1,600 consolidated lawsuits from across the country, including regions hard-hit by the crisis, like Portsmouth, Ohio, and Huntington, W.Va. On Monday, the judge overseeing that case remov...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime opioid crisis Source Type: news
On tour in Africa, American officials said the U.S. would keep providing aid. But Congo ’s response has been uneven, and the former health minister has been jailed.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Ebola Virus Epidemics World Health Organization State Department Centers for Disease Control and Prevention Congo, Democratic Republic of (Congo-Kinshasa) Tanzania Uganda Source Type: news
Gov. Gavin Newsom pushed back against criticism of his handling of the new vaccine laws, which prompted protests at the state Capitol.
Source: L.A. Times - Health - Category: Consumer Health News Authors: Source Type: news
Health officials recorded no new cases of measles in the United States last week, marking the first week without new cases of the disease since January, amid an outbreak largely linked to parents who declined to vaccinate their children.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Michigan's governor is prepared to issue anemergency executive order that would ban the sale of flavored electronic cigarettes effective immediately (once the order is filed). I have already explained why this law will be a public health disaster. It will have three major deleterious health effects:1. It will cause many ex-smokers to return to smoking as their vaping products are taken off the market.2. It will create a new black market for flavored e-liquids that does not exist today. As we are finding out, black market products can be extremely dangerous.3. It will cause many youths who are currently vaping e-liquids to ...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
Lawyers for cities and counties suing drug companies over the opioid epidemic on Monday objected to a bid by pharmaceutical distributors and pharmacies to disqualify the federal judge overseeing the cases, saying it had no basis and came too late.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
More News: Coronavirus | Epidemics | Epidemiology | MERS | Middle East Health | Outbreaks | Pneomococcal Vaccine | Pneumonia | Respiratory Medicine | SARS | Study | Vaccines | Virology | Zoonoses