Structural insights into coronavirus entry

Publication date: Available online 22 August 2019Source: Advances in Virus ResearchAuthor(s): M. Alejandra Tortorici, David VeeslerAbstractCoronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbreaks in humans with a fatality rate of 35%. SARS-CoV and MERS-CoV are zoonotic viruses that crossed the species barrier using bats/palm civets and dromedary camels, respectively. No specific treatments or vaccines have been approved against any of the six human coronaviruses, highlighting the need to investigate the principles governing viral entry and cross-species transmission as well as to prepare for zoonotic outbreaks which are likely to occur due to the large reservoir of CoVs found in mammals and birds. Here, we review our understanding of the infection mechanism used by coronaviruses derived from recent structural and biochemical studies.
Source: Advances in Virus Research - Category: Virology Source Type: research

Related Links:

Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
The coronavirus epidemic has hit buffets hard. Relying on sneeze guards and the good manners and hygiene of other diners is particularly problematic now.
Source: Arkansas Business - Health Care - Category: American Health Source Type: news
Dr. R. Pierce Osborne II, the dental association chief, touts COVID-19 precautions and says not a single U.S. virus case has been traced to a dental visit.
Source: Arkansas Business - Health Care - Category: American Health Source Type: news
Paul Kreth, co-owner and CEO of Shorty Small’s in Little Rock, told Arkansas Business that he and his team “just want to claim that we’re doing the best that we can possibly do” when it comes to protecting diners and the restaurant’s employees from the coronavirus.
Source: Arkansas Business - Health Care - Category: American Health Source Type: news
Abstract Zika virus (ZIKV) is a mosquito-borne flavivirus associated with Congenital Zika Syndrome (CZS), reflecting a wide range of congenital abnormalities in fetuses and infants infected with ZIKV before birth. ZIKV infections have also been associated with the neurological autoimmune disorder known as Guillian-Barré syndrome (GBS). To date, no vaccines or antiviral strategies are licensed for ZIKV. We used rational design to develop a novel ZIKV vaccine candidate using a Woodchuck Hepatitis core Antigen (WHcAg) Virus-Like Particle (VLP) scaffold for displaying selected antigens from the ZIKV Envelope (E...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Publication date: Available online 1 August 2020Source: Preventive Veterinary MedicineAuthor(s): Sarah E. Lauterbach, Sarah W. Nelson, Alison M. Martin, Michele M. Spurck, Dimitria A. Mathys, Dixie F. Mollenkopf, Jacqueline M. Nolting, Thomas E. Wittum, Andrew S. Bowman
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Legislation that would grant additional paid sick leave to employees during the Covid-19 outbreak is moving on Beacon Hill after securing the approval of a key panel.
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Residents in state of Victoria wake up after first night of curfew;‘major incident’ declared in Manchester;Nancy Pelosi says she has no confidence in Birx over handling of pandemic. Follow the latest updatesCoronavirus global report: ‘response fatigue’ fears as Mexico hits 9,000 daily casesVictoria announces stage four coronavirus lockdown restrictions including overnight curfewGreater Manchester declares major incident after rise in Covid-19 casesSee all our coronavirus coverage1.06amBSTThe US reported 1.87 million cases in July alone, according to the Johns Hopkins University tracker.This figure i...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Australia news US news UK news Science Infectious diseases Source Type: news
Abstract On January 31, 2020, novel coronavirus (nCoV), a zoonotic virus yet to be identified into the taxonomy, created a powerful ripple through mankind that the World Health Organization has declared a global health emergency.1 This is definitely not the first time that an alarm has been rung by this family of viruses. Epidemic impact of severe acute respiratory syndrome (SARS) due to SARS CoV and Middle East respiratory syndrome (MERS) by MERS CoV has engraved their place in the scientific literature.2 In general, CoV is known to cause respiratory diseases in humans and accounts for one-third of common cold in...
Source: J Contemp Dent Pract - Category: Dentistry Authors: Tags: J Contemp Dent Pract Source Type: research
Publication date: Available online 4 February 2020Source: Microbes and InfectionAuthor(s): Jieliang ChenAbstractA zoonotic coronavirus, labeled as 2019-nCoV by The World Health Organization (WHO), has been identified as the causative agent of the viral pneumonia outbreak in Wuhan, China, at the end of 2019. Although 2019-nCoV can cause a severe respiratory illness like SARS and MERS, evidence from clinics suggested that 2019-nCoV is generally less pathogenic than SARS-CoV, and much less than MERS-CoV. The transmissibility of 2019-nCoV is still debated and needs to be further assessed. To avoid the 2019-nCoV outbreak turnin...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
More News: Coronavirus | Epidemics | Epidemiology | MERS | Middle East Health | Outbreaks | Pneomococcal Vaccine | Pneumonia | Respiratory Medicine | SARS | Study | Vaccines | Virology | Zoonoses