The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms

ConclusionsOverall, our results show that the activity of pepR on pre-formed biofilms is controlled by its diffusion along the biofilm layers, an effect that can be counteracted by an additional administration of peptide. Our study sheds new light on the antibiofilm mechanism of action of antimicrobial peptides, particularly the importance of their diffusion properties through the biofilm matrix on their activity.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research