Catalytic cyanosilylation application and antitumor activity in osteosarcoma of a porous Gd(III)-based coordination polymer

Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Lei Wang, Gui-Bin XueAbstractSolvothermal reactions of 1, 3, 5-tris (4-carboxyphenyl)-benzene (H3BTB) with Gd(NO3)·6H2O gave rise to a new highly porous coordination polymer {[Gd(BTB)(H2O)](DMF)(H2O)}n (1) having three dimensional structure. In light of its highly rigid framework as well as the large one-dimensional triangular channel configuration that has abundant open metal sites, we can utilize the resulting activated 1a as effective Lewis catalysts for the acetaldehyde's cyanosilylation at room temperature. The comparison experiments reflect that the open Gd2+ sites, as catalytic activation sites, played a crucial part in heterogeneous catalysis. In connection to these, the possible catalysis mechanism has also been discussed in detail. Compound 1a inhibition against the cancer cell viability was detected by the CCK-8 assay. Besides, the cell colony formation assay was also carried out for the cell proliferation assay. Next, we further explored the mechanism of compound 1a against cancer cells, so the Annexin V-FITC/PI double staining assay was performed to determine the cell apoptosis.
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research

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Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
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Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
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Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research
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Source: eLife - Category: Biomedical Science Tags: Cancer Biology Cell Biology Source Type: research
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