Short communication: Adipogenic, metabolic, and apoptotic marker mRNA in cellular fractions of adipose tissue from chickens predisposed to be anorexic or obese

The objective of this study was to measure gene expression of various preadipocyte, proliferation, metabolic, and apoptotic markers in the stromal-vascular fraction and adipocytes from LWS and HWS adipose tissue. Although preadipocyte and proliferation markers were more highly expressed in the stromal-vascular fraction of LWS than HWS chicks, greater expression of granzyme-A and the presence of more annexin V-positive cells suggests that apoptosis may limit the adipogenic potential of adipocyte precursor cells and represent a novel mechanism that regulates the expansion of adipose tissue. Results provide insights on cellular mechanisms associated with adipose tissue development in the lean and obese state.Graphical abstract
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - Category: Biochemistry Source Type: research

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ConclusionPortal and mesenteric venous thrombosis after laparoscopic sleeve gastrectomy is an unusual complication but it has life threatening consequences if it is not diagnosed early and treated adequately. The patients with porto-mesenteric venous thrombosis (PMVT) usually present themselves with vague abdominal symptoms. As so, the physicians should have high index of suspicion to recommend computed tomography (CT) abdomen to confirm diagnosis and start adequate treatment.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 17 September 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Galyna V. Graham, Andrew McCloskey, Yasser H. Abdel-Wahab, J. Michael Conlon, Peter R. FlattAbstractPeptidase-resistant analogues of GLP-1 peptides from sea lamprey and paddlefish ([D-Ala2]palmitoyl-lamprey GLP-1 and [D-Ala2]palmitoyl-paddlefish GLP-1) produced significant (P ≤ 0.05) and concentration-dependent increases in insulin release from BRIN-BD11 clonal β-cells and from isolated mouse islets. Both analogues retained the ability of the native peptides to activate both the GLP-1 receptor (GLP1R) and ...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
AbstractArchaea, which form one of four domains of life alongside Eukarya, Bacteria, and giant viruses, have long been neglected as components of the human microbiota and potential opportunistic infectious pathogens. In this review, we focus on methanogenic Archaea, which rely on hydrogen for their metabolism and growth. On one hand, methanogenic Archaea in the gut are functional associates of the fermentative digestion of dietary fibers, favoring the production of beneficial short-chain fatty acids and likely contributing to the weaning reaction during the neonatal window of opportunity. On the other hand, methanogenic Ar...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsCancer patients were referred late to a dietitian, with multiple nutritional barriers. Most referrals were for established weight loss (WL). WL may be masked by pre-existing obesity. Almost half had missed earlier referral opportunities; screening was infrequent. Over one-quarter should have been re-referred sooner. There is a clear need for clinician education. Future research should investigate the optimal timing of dietitian referral and the best nutrition screening tools for use in cancer.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
The objective of this study was to measure gene expression of various preadipocyte, proliferation, metabolic, and apoptotic markers in the stromal-vascular fraction and adipocytes from LWS and HWS adipose tissue. Although preadipocyte and proliferation markers were more highly expressed in the stromal-vascular fraction of LWS than HWS chicks, greater expression of granzyme-A and the presence of more annexin V-positive cells suggests that apoptosis may limit the adipogenic potential of adipocyte precursor cells and represent a novel mechanism that regulates the expansion of adipose tissue. Results provide insights on cellul...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - Category: Physiology Authors: Tags: Comp Biochem Physiol A Mol Integr Physiol Source Type: research
In conclusion, neutralization of ACBP might constitute a strategy for treating obesity and its co-morbidities. PMID: 31422903 [PubMed - as supplied by publisher]
Source: Cell Metabolism - Category: Cytology Authors: Tags: Cell Metab Source Type: research
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Source: World Journal of Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
The research on how much poor/lack of sleep + stress can affect the body and increase your risk of multiple types of diseases (dementia, cancer, metabolic syndrome, etc) are vast and well supported. Today, this thought hit me hard when I thought back about how many of my friends in med school have become overweight with a beer gut, getting into the territory of anorexia, or worsening health status. I can only imagine how much residency can negatively affect your health and appearance. Is... The affect of stress and lack of sleep on health of people in medicine?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Medical Students - MD Source Type: forums
Conclusion: Obesity is a risk factor for depression. The shift from typical to atypical depression is due to an inhibitory effect of higher circulating leptin on HPA axis activity and subsequent decrease in the lipolytic effects of cortisol. PMID: 31347937 [PubMed - as supplied by publisher]
Source: The World Journal of Biological Psychiatry - Category: Psychiatry Authors: Tags: World J Biol Psychiatry Source Type: research
American culture seems obsessed with dieting. According to the Centers for Disease Control, almost 70% of Americans over the age of 20 are overweight, including 35% that are considered obese. In kids and teens, it’s 17%. Meanwhile, the cultural ideal is to be fit, thin, and trim. The quest for body perfection has created a U.S. weight loss industry that was estimated to be worth $68.2 billion in 2017. In 2018, the fitness industry topped $30 billion. While 45 million Americans go on a diet every year and 54 million Americans paid for gym memberships last year, the sad reality is that most diets fail and most pe...
Source: Psych Central - Category: Psychiatry Authors: Tags: Eating Disorders Exercise Healthy Living Avoidant Restrictive Food Intake Disorder Disordered Eating food aversion Muscle Dysmorphia Orthorexia unhealthy dieting Source Type: news
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