Streptococcus pneumoniae inhibits purinergic signaling and promotes purinergic receptor P2Y2 internalization in alveolar epithelial cells [Cell Biology]

In conclusion, our results show that S. pneumoniae directly inhibits purinergic signaling by inducing P2Y2 phosphorylation and internalization, resulting in the suppression of the calcium response of alveolar epithelial cells to ATP, thereby affecting cellular integrity and function.

Source: Journal of Biological Chemistry - August 22, 2019 Category: Chemistry Authors: Cynthia Olotu, Felix Lehmensiek, Bastian Koch, Martina Kiefmann, Ann-Kathrin Riegel, Sven Hammerschmidt, Rainer Kiefmann Tags: Microbiology Source Type: research