Perioperative combined administration of tranexamic acid and dexamethasone in total knee arthroplasty—benefit versus harm?

Background: The purpose of this study was to investigate the benefits and harm of combined administration of tranexamic acid (TXA) and dexamethasone (Dexa) in total knee arthroplasty (TKA). Methods: A total of 88 consecutive patients undergoing TKA for knee osteoarthritis were stratified in 2 groups. All surgeries were performed under general anesthesia. Brief, patients in the TXA + Dexa group (n = 45) received 10 mg Dexa just after the anesthesia, and repeated at 24 hours after the surgery; and patients in the TXA group (n = 43) received 2 ml of normal saline solution at the same time. The measured outcomes were the C-reactive protein (CRP) and interleukin-6 (IL-6) from preoperatively to postoperatively, and postoperative nausea and vomiting (PONV), fatigue, range of motion (ROM), length of stay (LOS), and the analgesic and antiemetic rescue consumption Results: The level of CRP and IL-6 in the TXA + Dexa group were lower than that in the TXA group at 24 hours (P 
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

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Authors: Chao Y, Zhang L, Zhang X, Ma C, Chen Z Abstract BACKGROUND The aim of this study was to explore the expression of miR-140 and miR-199 in synovia of patients with knee osteoarthritis (KOA) and its correlation with the progression of this disease. We used the Kellgren and Lawrence grading (KLG) system. MATERIAL AND METHODS There were 110 patients with early (KLG 2) stage KOA and 60 healthy individuals (control) included in this study. RESULTS The relative expression levels of miR-140 (1.07±0.091) and miR-199 (1.03±0.110) in synovia of the control group were higher than those of KOA groups (0.51...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Might the metabolic syndrome play a role in the pathogenesis of osteoarthritis?Arthritis Research &Therapy
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news
ConclusionOverall, our results suggest that G-Rb1 exerts cartilage protective effect on MIA induced ovariectomized OA rats, by inhibiting inflammatory mediators such as IL-6, IL-1β, MCP1/CCL2, COX-2, and PGE2. These results shed a light on possible therapeutic application of G-Rb1 in OA.Graphical abstract
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
AbstractPurposeLower limb malalignment is a strong predictor of progression in knee osteoarthritis. The purpose of this study is to identify the individual alignment variables that predict progression in early to moderate osteoarthritis of the knee.Method A longitudinal cohort study using data from the Osteoarthritis Initiative. In total, 955 individuals (1329 knees) with early to moderate osteoarthritis (Kellgren-Lawrence grade 1, 2 or 3) were identified. All subjects had full-limb radiographs analysed using the Osteotomy module within Medicad® Classic (Hectec GMBH) to give a series of individual alignment var...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Source: ClinicoEconomics and Outcomes Research - Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
We examined the association of three common chronic conditions (obesity, diabetes mellitus [DM], and cardiovascular disease [CVD]) with transitions among states of hip osteoarthritis (HOA).
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
The currently available evidence base of research papers evaluating changes in gait biomechanics after total ankle replacement and ankle arthrodesis is limited by a lack of prospective research, low sample sizes and heterogeneity in the patho-etiology of ankle osteoarthritis. Following total ankle replacement, improvements were demonstrated for spatio-temporal, kinematic and kinetic gait patterns compared to the pre-operative measures. Improvements in gait mechanics after ankle arthrodesis were limited to walking speed and ankle moment.
Source: Clinical Biomechanics - Category: Orthopaedics Authors: Tags: Review Source Type: research
Publication date: January–February 2020Source: Revista Española de Cirugía Ortopédica y Traumatología (English Edition), Volume 64, Issue 1Author(s): A. Abarquero-Diezhandino, G. Luengo-Alonso, D. Alonso-Tejero, E.J. Sánchez-Morata, C. Olaya-Gonzalez, J. Vilá y RicoAbstractBackground and aimsAt least 10% of ankle fractures involve the posterior malleolus of the tibia, which has been related to poorer long-term prognosis. Our aim was to analyse the clinical and functional outcomes of ankle fractures involving the posterior edge, treated surgically without direct reduction of t...
Source: Revista Espanola de Cirugia Ortopedica y Traumatologia - Category: Orthopaedics Source Type: research
Publication date: Available online 18 January 2020Source: Journal of Orthopaedic TranslationAuthor(s): Muzhi Li, Yifu Tang, Can Chen, Jiefu Zhou, Cheng Zheng, Huabin Chen, Hongbin Lu, Jin QuAbstractBackgroundMany orthopedic surgical procedures involve reattachment between tendon and bone. Whether bone–tendon healing is better facilitated by tendon fixation on a bone surface or within a tunnel is unknown. The purpose of this study was to comparatively evaluate the effects of bone surface versus bone trough fixation on bone–tendon healing in a rabbit patella–patellar tendon (PPT) injury model.MethodsThe rab...
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
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