Follow up after sample size re-estimation in a breast cancer randomized trial for disease-free survival

ConclusionsWe found that our re-estimation procedure performed reasonably well in estimating the control group failure probabilities at the time of re-estimation. Particularly for time-to-event outcomes, pre-planned blinded SSRE procedures may be the best option to aid in maintaining power.Trial registrationClinicalTrials.gov,NCT00201851. Registered on 9 September 2005. Retrospectively registered.
Source: Trials - Category: Research Source Type: clinical trials