DTaP-IPV-HepB-Hib Vaccine (Hexyon ® ): An Updated Review of its Use in Primary and Booster Vaccination

AbstractHexyon® is a fully-liquid, ready-to-use, hexavalent vaccine approved in the EU since 2013 for primary and booster vaccination in infants and toddlers from age 6  weeks against diphtheria, tetanus, pertussis, hepatitis B (HB), poliomyelitis, and invasive diseases caused byHaemophilus influenzae type b (Hib). While the source of HB antigen in Hexyon® is different from other vaccines, the rest of its valences have been extensively used in other approved vaccines. Hexyon® is highly immunogenic for all its component toxoids/antigens when used as primary and booster vaccine in infants and toddlers, irrespective of vaccination schedule. It provides durable protection against hepatitis B. Hexyon® can be used for a mixed primary series of hexavalent-pentavalent-hexavalent vaccines or as a booster in infants primed with Infanrix hexa ™ or pentavalent (whole-cell or acellular pertussis) vaccines. Coadministration of Hexyon® with other common childhood vaccines did not affect immune response to any vaccines. Hexyon® has a good reactogenicity/safety profile. The immunogenicity and safety profile of Hexyon® was similar to that of several approved vaccines, including Infanrix hexa ™. However, Hexyon® offers the convenience of full-liquid, ready-to-use formulation, which may minimize vaccination errors and preparation time. Thus, Hexyon® is a convenient, useful option for vaccination against childhood diseases caused by six major p...
Source: Pediatric Drugs - Category: Pediatrics Source Type: research

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The objectives of this study were to assess the immunization coverage of children aged 5-6 years and 13-14 years during the 2017-2018 school year, and to identify sociodemographic factors associated with full immunization in these children. MATERIALS AND METHODS: A descriptive cross-sectional school-based study was carried out. The population under study was a sample of schoolchildren aged 5-6 years and 13-14 years attending the second and 10th grades of primary and middle schools, respectively, located in the canton of Geneva, Switzerland. The data extracted from the vaccination cards included dates of administration...
Source: Archives de Pediatrie - Category: Pediatrics Authors: Tags: Arch Pediatr Source Type: research
Conditions:   Pertussis Immunisation;   Diphtheria Immunisation;   Polio Immunisation;   Hepatitis B Immunisation;   Haemophilus Influenzae Type B Immunisation;   Tetanus Immunisation;   Rotavirus Immunisation;   Pneumococcal Immunisation Interventions:   Biological: DTwP-HepB-Hib-IPV hexavalent vaccine (Diphtheria toxoid, Tetanus toxoid, whole cell pertussis, Hepatitis B surface antigen (HBsAg), Haemophilus influenzae type b, inactivated poliovirus);   Biological: DTwP-HepB-Hib pentavalent vaccine (Diphtheria toxo...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Fewer children are getting vaccinated in the Democratic Republic of the Congo (DRC) and the COVID-19 pandemic is almost certainly going to make matters worse, the United Nations Children’s Fund (UNICEF) says. If the trend continues, it could trigger a resurgence in deadly childhood diseases such as polio, chickenpox, measles, yellow fever, hepatitis B, diphtheria, tetanus, whooping cough and meningitis.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
Conclusion: Special attention should be paid to homeless children born outside France, with recent European and French recommendations confirming the need for catch-up vaccination in children with undocumented VC.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Alex Nowrasteh andAndrew C. ForresterThe international spread of the SARS ‐​CoV‐​2 virus that causes the disease COVID-19 has prompted many governments to close their borders. Immigration policy plays an important role in limiting the international spread of contagious diseases.Prior to the COVID-19 crisis,several commentators were concerned that immigrants – especially illegal immigrants – were spreading serious diseases in the United States. This blog post is the first in a series to answer the question of whether immigrants spread serious notifiable diseases other than COVID-19 in the ...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
A new hexavalent vaccine for use in children aged 6 weeks through 4 years has been approved by the FDA to prevent diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b, and hepatitis B.Morbidity &Mortality Weekly Report
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Public Health & Prevention Journal Article Source Type: news
A new combination vaccine to prevent diphtheria, tetanus, whooping cough, polio, Haemphilus influenzae type b disease, and hepatitis B has been licensed, but won't be available before 2021.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Diphtheria Vaccination Hepatitis B Vaccination MMWR Morbidity & Mortality Weekly Report Pertussis Vaccination Tetanus Vaccination Vaccine-Preventable Diseases and Specific Vaccines Whooping cough Source Type: news
Authors: Albertsen N, Lynge AR, Skovgaard N, Olesen JS, Pedersen ML Abstract In order to estimate the current coverage rate among all children in Greenland, we conducted an observational cross-sectional study identifying all children in Greenland eligible for a vaccination between 1 March 2018 and 16 June 2019. we found an overall national coverage of 85.4%. The national coverage for the vaccinations given at birth was 97.1%, dropping to 94.3%, 87.7% and 83.6% at ages 3, 5 and 12 months. Among children eligible for the Measles, Mumps and Rubella-vaccinations, the national coverage was 76.9% for children aged 15 mon...
Source: International Journal of Circumpolar Health - Category: International Medicine & Public Health Tags: Int J Circumpolar Health Source Type: research
ConclusionsReceiving the birth dose is positively associated with up-to-date status later in childhood, highlighting the importance of starting vaccination early. The association is insensitive to confounding by factors observed in National Immunization Survey-Child, but investigation of unobserved factors such as vaccine hesitancy could provide critical information to guide intervention strategy.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Abstract Hexavalent vaccines containing diphtheria, tetanus, pertussis, Haemophilus influenzae type b, poliomyelitis, and hepatitis B virus antigens have the potential to be used for the primary series in India (6, 10, 14 weeks of age) and the toddler booster dose. Three hexavalent vaccines are available in India: DTwP-Hib/HepB-IPV (wP-hexa), DTaP-IPV-HB-PRP~T(2aP-hexa), and DTaP-HBV-IPV/Hib (3aP-hexa). In the three published phase-3 Indian studies, pertussis 'vaccine response' rates 1 month after a 6-10-14-week primary series were 68.4-75.7% for wP-hexa, 93.8-99.3% for 2aP-hexa, and 97.0-100% for 3aP-hexa; seropr...
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research
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