P15. Human mesenchymal stem cells exhibit increased proliferation on rough titanium substrates

In the majority of orthopaedic surgeries, osseointegration between an implant and surrounding bone is crucial to achieving short- and long-term stability of the implant. Since an implant's surface properties directly influence the cellular response at the cell-material interface, a number of techniques exist to modify the surface characteristics of titanium (Ti)-based implants, with the objective of achieving improved osseointegration of the implant and surrounding bone. Many of these processes, such as grit-blasting and acid-etching, create a roughened surface in a random, poorly controlled manner.

Source: The Spine Journal - August 23, 2019 Category: Orthopaedics Authors: Margaret R. Van Horn, Samantha Greeley, Brandon Bucklen Source Type: research