2017 Research Grant: NF1 and KEAP1 mutations are correlated to increased rates of local failure after radiation therapy for spine metastases from non-small cell lung cancer

The spine is a common site of metastasis from non-small cell lung cancer (NSCLC), a disease hallmarked by heterogeneity in molecular alterations. Traditional spine radiation treatment (RT) with conventionally fractionated external beam radiation therapy (cEBRT) is associated with high local failure (LF) rates in patients surviving more than 12 months. Treatment with advanced techniques including stereotactic body radiation therapy (SBRT) significantly reduces LF. We hypothesized that specific genomic mutations in NSCLC metastases impart increased risk of LF, and that treatment with SBRT would prevent LF in metastases harboring such alterations.

Source: The Spine Journal - August 23, 2019 Category: Orthopaedics Authors: Erik S. Anderson, Natalie Lockney, Dennis Lockney, Robert Samstein, Daniel Higginson, Mark H. Bilsky, Ilya Laufer, Yoshiya Yamada, Adam M. Schmitt Source Type: research