Koumiss consumption induced changes in the fecal metabolomes of chronic atrophic gastritis patients

Publication date: November 2019Source: Journal of Functional Foods, Volume 62Author(s): Changkun Li, Xiufang Liu, Haoqian Wang, Hui Fan, Zhihui Mi, Lai-yu Kwok, Heping Zhang, Bilige Menghe, Zhihong Sun, Yongfu ChenAbstractOur previous research showed that koumiss intervention could alleviate symptoms of chronic atrophic gastritis (CAG) via the modulation of gut microbiota. The present work aimed to further decipher the mechanism of the observed functional effect by analyzing changes in the fecal metabolomes of these patients. Significant modulation was observed in the levels of metabolites relating to several pathways, namely biosynthesis of primary and secondary bile acid, as well as metabolism of unsaturated fatty acid, linoleic acid and arachidonic acid, phenylalanine, and retinol. Koumiss treatment also decreased the level of some fecal proinflammatory markers, as evidenced by significant decrease in the fecal interleukin 38 (P < 0.05) and numerical decrease in tumor necrosis factor-α after 60-days of koumiss consumption. Our data together suggest that koumiss can serve as functional food that improves CAG symptoms via integrative modulation of the host immunity, gut microbiota and metabolome.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research