Networks Disrupted in Linguistic Variants of Frontotemporal Dementia

The non-fluent / agrammatic variant of primary progressive aphasia (nfvPPA) and semantic variant (svPPA) of frontotemporal dementia (FTD) are neurodegenerative diseases. Previous works have shown alterations of fractional anisotropy (FA) and mean diffusivity (MD) from diffusion tensor images (DTIs). This manuscript is aimed at using DTI images to build a global tractography and to identify atrophy patterns of subcortical networks in each variant. Twenty patients with svPPA, 20 patients with nfvPPA, and 26 patients with behavioral variant of FTD (bvFTD) were included. An analysis based on the connectivity of structural networks showed changes in FA and MD in svPPA and nfvPPA with respect to bvFTD. Much damage in the internal networks of the left temporal lobe was found in svPPA patients; in contrast, patients with nfvPPA showed atrophy in networks from the basal ganglia to motor and premotor areas. Those findings support the dual stream model of speech and language

Source: Frontiers in Neurology - August 22, 2019 Category: Neurology Source Type: research