Association of HIF1A and Parkinson ’s disease in a Han Chinese population demonstrated by molecular inversion probe analysis

In conclusion, our study further indicates that HIF1A plays a role in PD pathogenesis.
Source: Neurological Sciences - Category: Neurology Source Type: research

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The objective of the current study was to investigate the change in IPS and attention during head-up tilt (HUT) in patients with NOH compared to controls. Cognitive function was assessed in the supine and HUT positions using the symbol digit modalities test (SDMT) which assesses IPS and the Stroop Test which measures attention. 40 participants completed the study, 20 controls (age 64.50 ± 9.25) and 20 NOH patients (age 69.55 ± 7.43) with associated conditions of Parkinson's disease (n = 11), multiple systems atrophy (n = 3), early Lewy body dementia (n = 1) and idiopathic NOH (n = 5). ...
Source: Physiology and Behavior - Category: Physiology Source Type: research
ConclusionRecognition of emotional stimuli was more accurate compared to non-emotional stimuli in AD, left-sided PD and HC; right-sided PD did not show sensitivity to the emotional valence of the stimuli suggesting the involvement of the nigrostriatal, mesocortical and mesolimbic circuitry of the left hemisphere in the emotional-reward system related to the aesthetic experience.
Source: Neurological Sciences - Category: Neurology Source Type: research
CONCLUSIONS: Our findings suggest that PTT is beneficial to improve reactive balance in PwPD. Further, PTT appeared to be effective only for a part of PwPD, especially for those with lower balance and cognitive function, which needs further attention.Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, PMID: 31517749 [PubMed - in process]
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: J Neurol Phys Ther Source Type: research
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Source: Journal of Neurologic Physical Therapy - Video - Category: Physiotherapy Source Type: video
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Source: Journal of Neurologic Physical Therapy - Video - Category: Physiotherapy Source Type: video
AbstractIt has been suggested that extracellular alpha synuclein ( αSyn) can mediate neuroinflammation in Parkinson's disease, and that αSyn affects B‐cell maturation. However, the function of αSyn in T cells is poorly understood. We hypothesized that αSyn can affect CD4+ T ‐cell proliferation and activity. We found that αSyn deficiency exacerbates disease progression in 8 weeks old C57BL6/J EAE‐induced mice, and that αSyn‐deficient CD4+ T cells have increased pro ‐inflammatory response to myelin antigen relative to wild‐type cells, as measured by cytokine secretion of interl...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: This educational program did not reduce the risk of falls but it improved the ability to carry out activities of daily living and decreased participation restrictions in people with neurological conditions.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
AbstractMitochondrial complex I damage and oxidative stress play critical roles in the degeneration of dopaminergic (DA) neurons during the progression of Parkinson's disease (PD). Our previous study showed that NADH dehydrogenase 6 (ND6), exclusively regulated by mitochondrial myocyte enhancer factor 2D (MEF2D), was critical for mitochondrial complex I assembly. Recently, we found that Salidroside (Sal), isolated from Rhodiola rosea L., protected DA neurons by regulating oxidative stress ‐related mitochondrial pathways. Here, we investigated whether the mitochondrial MEF2D‐ND6 pathway was involved in the neuroprotecti...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Original Article Source Type: research
Transcranial non-invasive brain stimulation (NIBS) techniques include particularly repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), although other non-invasive stimulation techniques have also been employed. The rTMS uses a rapidly changing magnetic field to induce currents and action potentials in underlying brain tissue. The tDCS involves the application of weak (1 –2mA) electrical currents to modulate neuronal membrane potential. Although the precise mechanisms of NIBS aftereffects have not been fully elucidated, rTMS has been shown to modulate several neurotr...
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Conclusions:ID comorbid to PD is associated with the classic psychological factors perpetuating ID in neurological disease-free individuals with insomnia. Target-oriented interventions for instance cognitive behavioral therapy for chronic insomnia should be considered as a treatment approach for ID comorbid to PD.Citation:Lebrun C, Gély-Nargeot M-C, Maudarbocus KH, Rossignol A, Geny C, Bayard S. Presleep cognitive arousal and insomnia comorbid to parkinson disease: evidence for a serial mediation model of sleep-related safety behaviors and dysfunctional beliefs about sleep.J Clin Sleep Med. 2019;15(9):1217–1224.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
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