Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF- β/Smad signaling pathway.

CONCLUSION: During liver fibrosis, BMP7 protein expression first increases and then decreases. This changing trend is associated with inhibition of BMP7 expression by sustained upregulation of TGF-β1 in a time- and dose-dependent manner. Exogenous BMP7 could selectively regulate TGF-β/Smad pathway-associated factors to inhibit activation, migration, and proliferation of HSCs and exert anti-liver fibrosis functions. Exogenous BMP7 has the potential to be used as an anti-liver fibrosis drug.
PMID: 31435175 [PubMed - in process]

Source: World Journal of Gastroenterology - August 13, 2019 Category: Gastroenterology Authors: Zou GL, Zuo S, Lu S, Hu RH, Lu YY, Yang J, Deng KS, Wu YT, Mu M, Zhu JJ, Zeng JZ, Zhang BF, Wu X, Zhao XK, Li HY Tags: World J Gastroenterol Source Type: research