Cancer and Cerebrovascular Disease

AbstractPurpose of ReviewTo review the latest information about the interactions between cancer and cerebrovascular disease.Recent FindingsAdditional data support the finding that both ischemic and hemorrhagic stroke are important complications of cancer or its treatment. Reperfusion therapy is being given successfully to patients with stroke complicating cancer.SummaryHemorrhagic stroke may occur with metastatic disease to the brain, coagulopathies from cancer, in particular leukemia, or as complications of chemotherapy. Ischemic stroke also may be a complication of metastatic disease with local invasion of vessels, a pro-thrombotic disorder such as non-bacterial thrombotic endocarditis (NBTE) or disseminated intravascular coagulation (DIC), or secondary to chemotherapy. Stroke also is a potential consequence of radiation therapy to the head and neck. Venous sinus thrombosis may develop with hematologic malignancies or chemotherapy. Although many patients will have a history of cancer at the time of stroke, a cerebrovascular event may be the initial manifestation of a malignancy.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research

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Publication date: Available online 18 September 2019Source: Biosensors and BioelectronicsAuthor(s): Lingling Li, Bing Han, Ying Wang, Jing Zhao, Ya CaoAbstractMembrane protein, a novel surface biomarker, plays an important role in cell recognition and disease diagnosis. Accurate recognition of membrane protein ensure high specificity of cell identification, while introducing signal molecules onto cell membrane is critical to achieve high sensitivity. In this work, we introduced a simple and universal signal labeling approach for cancer cell detection based on mild reduction-mediated cell engineering. This approach included...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: 15 January 2020Source: Journal of Molecular Structure, Volume 1200Author(s): Reena R. Varma, Bharat H. Pursuwani, E. Suresh, Bhupesh S. Bhatt, Mohan N. PatelAbstractA series of seven rhenium(I) complexes [(Re(CO)3L1−7)Cl], where L = 2-(1-phenyl-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-3-yl)pyridine (L1), 2-[5-(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]pyridine (L2), 1-(6-bromopyridin-2-yl)ethan-1-one (L3), 1-(6-methoxypyridin-2-yl)ethan-1-one (L4), 4-phenyl-2-(pyridin-2-yl)quinoline (L5), 6-chloro-4-phenyl-2-(pyridine-2-yl)quinolone (L6), 6-chloro-4-(2-chlorophenyl)-2-(pyridine-2-yl)quinolon...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
CONCLUSION: Parasitic diseases, such as those caused by Fasciola hepatica, should be kept in mind in the differential diagnosis of primary or metastatic liver tumors, such as colorectal cancer liver metastasis, in patients living in endemic areas. PMID: 31528248 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
In conclusion, even if it is still totally hypothetical, our point of view may have clinical consequences, especially when deciding to perform a liver biopsy in patients with a higher liver stiffness and suspending the anticoagulation in patients with PVT and no detectable prothrombotic factors. PMID: 31528244 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Conclusions: Round-mailed FIT kits with phone call reminders were an effective intervention, nearly doubling the screening rate in underserved regions of Korea. PMID: 31530737 [PubMed - as supplied by publisher]
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
Publication date: Available online 18 September 2019Source: Protein Expression and PurificationAuthor(s): Nazimuddin Khan, Jino Park, William L. Dean, Robert D. Gray, William Tse, Donghan Lee, T. Michael SaboAbstractThe protein ALL1 fused from chromosome 1q (AF1q) is overexpressed in a variety of cancers and acts to activate several signaling pathways that lead to oncogenesis. For example, AF1q has been shown to interact with T-cell Factor 7 (TCF7; also known as TCF1) from the Wnt/β-catenin pathway resulting in the transcriptional activation of the CD44 and the enhancement of breast cancer metastasis. Despite the impo...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: Available online 18 September 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Rolf Jorde, Tom Wilsgaard, Guri GrimnesAbstractVitamin D deficiency is associated with diabetes, cancer, immunological and cardiovascular diseases as well as increased mortality. It has, however, been difficult to show a causal relation in randomized, controlled trials. Mendelian randomization studies provide another option for testing causality, and results indicate relations between the serum 25-hydroxyvitamin D (25(OH)D) level and some diseases, including mortality. We have from the Troms&oslas...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 18 September 2019Source: PeptidesAuthor(s): Aneta Lidia Zygulska, Agata Furgala, Jolanta Kaszuba-Zwoińska, Krzysztof Krzemieniecki, Krzysztof GilAbstractPhysiological roles of enterohormones such as secretion, absorption and digestion were supported by clinical data. Overexpression of cholecystokinin (CCK), neurotensin (NT) and vasoactive intestinal peptide (VIP) receptors occur in gastrointestinal (GI) malignancies. The aim of the paper was to compare plasma levels of CCK, peptide YY (PYY), VIP and NT in patients with gastrointestinal malignancies and healthy controls. The study include...
Source: Peptides - Category: Biochemistry Source Type: research
ConclusionsLow-pressure CLC column exhibited greater potential than high-pressure CLC column, and can be thus recommended for its intended use in speciation analysis of metal-based biomolecules.Graphical abstract
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Authors: Archer DF, Simon JA, Portman DJ, Goldstein SR, Goldstein I Abstract Introduction: Vulvovaginal atrophy (VVA), a component of the genitourinary syndrome of menopause, is a progressive condition due to decline in estrogen leading to vaginal and vulvar epithelial changes. Accompanying symptoms of dryness, irritation, burning, dysuria, and/or dyspareunia have a negative impact on quality of life. Ospemifene is a selective estrogen receptor modulator (SERM) approved by the FDA for moderate to severe dyspareunia and vaginal dryness due to postmenopausal VVA. Areas covered: PubMed was searched from inception to M...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
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