Predictive markers of lymphomagenesis in Sj ögren's syndrome: From clinical data to molecular stratification.

Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification. J Autoimmun. 2019 Aug 17;:102316 Authors: Kapsogeorgou EK, Voulgarelis M, Tzioufas AG Abstract Sjögren's syndrome (SS) is a chronic systemic autoimmune disease, affecting predominantly the exocrine glands, a large array of systemic manifestations and high risk of lymphoma development. The latter constitutes the major adverse outcome of SS contributing in the increased morbidity and mortality of the disease. The vast majority of lymphomas in SS are B-cell non-Hodgkin's lymphomas (NHL), primarily indolent mucosa-associated lymphoid tissue (MALT) lymphomas, followed by nodal marginal zone lymphomas (NMZL) and diffuse large B cell lymphomas (DLBCL). In the last 3 decades and due to the adverse impact of NHL in disease outcome, an effort has been undertaken to identify markers and models predicting patients with SS at high risk for lymphoma development. Several epidemiological, clinical, laboratory and histological parameters, some of which are evident at the time of SS diagnosis, were proved to independently predict the development of NHL. These include salivary gland enlargement, skin vasculitis/purpura, glomerulonephritis, peripheral neuropathy, Raynaud's phenomenon, lymphadenopathy, splenomegaly, cytopenias, hypocomplementemia, cryoglobulinemia, rheumatoid factor, anti-Ro/La autoantibodies, hypergammaglobulinemia, serum monoclonal gammopa...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research

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Publication date: 17 September 2019Source: Cell Reports, Volume 28, Issue 12Author(s): Leandro Pires Araujo, Juliana Terzi Maricato, Marcia Grando Guereschi, Maisa Carla Takenaka, Vanessa M. Nascimento, Filipe Menegatti de Melo, Francisco J. Quintana, Patrícia C. Brum, Alexandre S. BassoSummaryNoradrenaline (NE), the main neurotransmitter released by sympathetic nerve terminals, is known to modulate the immune response. However, the role of the sympathetic nervous system (SNS) on the development of autoimmune diseases is still unclear. Here, we report that the SNS limits the generation of pathogenic T cells and...
Source: Cell Reports - Category: Cytology Source Type: research
Authors: Petrakis I, Kontogiorgis C, Nena E, Athanasakis K, Gougoula V, Kotsianidis I, Constantinidis TC Abstract Introduction: Real-world effectiveness of hemato-oncology pharmaceuticals may not necessarily mimic clinical trial efficacy results, mainly due to demographic and clinical practice variability. The aim of this review was to systematically assess the availability of real-world evidence (RWE) and the transferability of clinical trial (CT) efficacy results to real life, for novel agents recently approved to manage lymphomas, leukemias and multiple myeloma. This is the largest cross-indication review compar...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Cakin MC, Ozdemir B, Kaya-Dagistanli F, Arkan H, Bahtiyar N, Anapali M, Akbas F, Onaran I Abstract Previous in vitro studies suggest a direct relevance for the peptide-free lipid fraction (LF) of platelet-rich plasma (PRP) in biological mechanisms related to wound healing. However, there are no scientific reports to date on the wound healing activities of this lipid component in vivo. Thus, the present study provides a scientific evaluation for the wound healing potential of the lipid portion of the activated PRP. For the wound healing activity assessment, in vivo full-thickness excisional wounds were crea...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Conclusions: The percentage of individuals sensitized to inhalants in CD and to inhalants and foods in UC, were higher than corresponding results in BD. However, whereas allergen positive reactions in CD were comparable to those in BD, they were reduced in UC because of the few UC reactions to food allergens. This contrasts previous data and the study also points to sensitization to inhalants as a potential factor in the complex pathogenesis of IBD. PMID: 31524013 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conditions:   Chronic Lymphocytic Leukemia;   Small Lymphocytic Lymphoma Intervention:   Drug: Ibrutinib Sponsors:   The First Affiliated Hospital with Nanjing Medical University;   Xian-Janssen Pharmaceutical Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   B-cell Acute Lymphoblastic Leukemia;   Diffuse Large B-cell Lymphoma Intervention:   Biological: Tisagenlecleucel Sponsor:   Novartis Pharmaceuticals Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Non-hodgkin Lymphoma,B Cell Intervention:   Drug: Acalabrutinib Sponsor:   Seoul National University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this report, we present a patient with Raynaud’s phenomenon refractory to standard therapies whose symptoms resolved after treatment with BTX-A. Follow-up with the patient after one and five years showed no relapse or recurrence of symptoms. J Drugs Dermatol. 2019;18(9):943-945. PMID: 31524993 [PubMed - in process]
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Roche has won the U.S. Food and Drug Administration's breakthrough therapy tag for its drug Gazyva in lupus nephritis, the Swiss drugmaker said on Wednesday, boosting its efforts to recycle the 2013-approved lymphoma medicine for new indications.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Date: Wednesday, 09 25, 2019; Speaker: Mark A. Ahlman, MD, , Staff Clinician, Nuclear Medicine Section, , Radiology and Imaging Sciences, CC; Peter C. Grayson, MD, MSc , Tenure-Track Investigator and Head, Vasculitis Translational Research , Program and Associate Director, Fellowship Program, ; Building: Building 10 (Clinical Center); Masur Auditorium; CME Credit; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
More News: Allergy & Immunology | Autoimmune Disease | Brain | Epidemiology | Glomerulonephritis | Hodgkin's Disease | Laboratory Medicine | Lymphoma | Men | Neurology | Peripheral Neuropathy | Raynaud's Phenomenom | Rheumatology | Skin | Skin Biopsy | Vasculitis