Current controversies in tubal disease, endometriosis, and pelvic adhesion
Reproductive surgery for proximal and distal tubal occlusion, as well as for reversal of tubal ligation, may be an alternative or an adjunct to IVF. Surgery for adenomyosis and endometriosis, including endometriomas, may be considered for the treatment of infertility and/or pelvic pain but carries the risks of surgical complications and diminished ovarian reserve. A greater understanding of the pathogenesis of postoperative peritoneal adhesion formation is needed to develop more effective preventive measures to optimize the clinical results of surgery.
ConclusionGreater awareness of HWWS will lead to earlier detection and is the key to alleviating patient suffering and avoiding potentially severe complications.
Modifiable risk factors such as diet may be important in both the etiology and progression of endometriosis as well as the prevalence of pain symptoms and infertility associated with this condition. In adults, higher intake of dairy has been associated with lower risk of endometriosis diagnosis. There is currently no literature on whether dairy intake during adolescence - a potentially critical window of exposure - influences endometriosis risk.
ConclusionsOur data confirm that endometriosis is a disease which probably progresses from adolescence until the adult period, when symptoms (pain or infertility) become debilitating and require surgery. Our data suggest that policies relating to the prevention and early diagnosis of endometriosis should focus on women under the age of 25 years.
ConclusionTraditionally only pathologies of the uterus and ovaries are assessed during a routine pelvic ultrasound. Here we demonstrate that the routine ultrasound examination can easily be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments to evaluate structural mobility and to look for deep infiltrating endometriotic nodules, so women suffering from deep infiltrating endometriosis can benefit from a pre-operative diagnosis and subsequently a single, well-planned procedure in the hands of a well-prepared team.
Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6% to 10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be used for patients wishing to become pregnant. Despite the high morbidity, the pathogenesis of endometriosis has not been well elucidated. Several inflammatory cytokines are reported to participate in the onset of endometriosis. Here, we examined the role of interleukin (IL)-1/IL-33 signaling in the develop...
Publication date: Available online 22 July 2019Source: International Journal of Surgery Case ReportsAuthor(s): Rahul Gupta, Arvind K Singh, Waad Farhat, Houssem Ammar, Mohamed Azzaza, Abdkader Mizouni, Sami lagha, Mehdi Ben Latifa, Amal Bouazzi, Ali Ben AliAbstractIntroductionPatients with appendicular endometriosis (AE) constitute
ConclusionsThese findings show the utility and reliability of multiplex arrays in deciphering new biomarker panels for disease detection and may offer clues for understanding this mysterious disease.
The objective herein was to determine reproducible and consistent findings regarding specific immune cell populations and their abundance, steroid hormone responsiveness, functionality, activation states, and markers, locally and systemically in women with and without endometriosis.SEARCH METHODSA comprehensive English language PubMed, Medline and Google Scholar search was conducted with key search terms that included endometriosis, inflammation, human eutopic/ectopic endometrium, immune cells, immune population, immune system, macrophages, dendritic cells (DC), natural killer cells, mast cells, eosinophils, neutrophils, B...
Conclusion: The results of this study will provide reliable evidence for the selection of clinical treatment program and guideline development. PROSPERO registration number: CRD42019127781.
CONCLUSIONS: In this case, as in others, nonspecific and variable symptoms may delay the diagnosis, which may lead to late complications such as endometriosis, adhesion syndrome, collections and infertility. Treatment suppresses pain, improves reproductive capacity and prevents late complications. PMID: 31223131 [PubMed - in process]