Clinical presentation, management and follow-up of 83 patients with Leydig cell tumors of the testis: a prospective case-cohort study

AbstractSTUDY QUESTIONWhen should ‘not so rare’ Leydig cell tumors (LCTs) of the testis be suspected, diagnosed, and treated?SUMMARY ANSWERLCTs are more frequent than generally believed, are associated with male infertility, cryptorchidism and gynecomastia, and should be treated conservatively (in compliant patients) with active surveillance, which appears to be a safe alternative to surgical enucleation.WHAT IS KNOWN ALREADYIncreasing referrals for testicular imaging have led to an increase in findings of LCTs. The features and natural history of these tumors remain largely unknown, as the available studies are small and heterogeneous. LCTs were previously treated aggressively and follow-up data are lacking.STUDY DESIGN, SIZE, DURATIONA case-cohort study of consecutive patients diagnosed with LCTs over a 10-year period was prospectively enrolled from 2009 to 2018 and compared to matched cohorts of patients with seminomas or no testicular lesions screened in the same timeframe.PARTICIPANTS/MATERIALS, SETTING, METHODSOf the 9949 inpatients and outpatients referred for scrotal ultrasound, a total of 83 men with LCTs were included. Enrolled subjects underwent medical history and clinical examination and were asked to undergo routine blood tests, hormone investigations (FSH, LH, total testosterone, estradiol, inhibin B, sex hormone-binding globulin (SHBG), prolactin), and semen analysis. Patients who consented also underwent contrast-enhanced ultrasound, elastography,...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research

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Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
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Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Journal Article Source Type: news
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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