Response to: One size does not fit all —application of accelerometer thresholds in chronic disease

We thank Dibbenet al. for their comments on our paper.1 A concern was raised that our analysis might introduce differential bias between those with vs those without chronic disease, through the use of a fixedy-axis threshold (100  mg) to determine whether an individual is likely to be moderately active at any given time. In an ideal scenario, we would have access to validation datasets in a large sample of healthy and diseased individuals. Unfortunately, such datasets simply do not exist at present. The heart failure validation data shared by Dibben and colleagues is potentially relevant but currently unpublished. At present, published validation data is only available on healthy individuals,2 which we acknowledge as a potential limitation in our paper.
Source: International Journal of Epidemiology - Category: Epidemiology Source Type: research