A Single Enhanced Dual-Energy CT Scan May Distinguish Lung Squamous Cell Carcinoma From Adenocarcinoma During the Venous phase

ConclusionThe iodine quantification parameters derived from enhanced DE-CT during the VP may be useful for distinguishing lung squamous cell carcinoma from adenocarcinoma.
Source: Academic Radiology - Category: Radiology Source Type: research

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Background: Serum tumor markers carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cytokeratin 19 fragment (CYFRA21-1) and squamous-cell carcinoma-related antigen (SCC-Ag) are routinely used for monitoring the response to chemotherapy or targeted therapy in advanced-stage non-small cell lung cancer (NSCLC), however their role in immunotherapy remains unclear. The aim of this study was to investigate whether dynamics of these serum markers were associated with the efficacy and prognosis of Chinese late-stage NSCLC patients treated with programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitors.M...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
242Introduction: Immune checkpoint inhibitors (IOs) have a different mechanism of action as compare to cytotoxic drugs by reactivating adaptive immune system. This unique mechanism poses a challenge to evaluate response to therapy by computed tomography (CT). We herewith compare the immune response evaluation criteria in solid tumors (iRECIST) to immune adaptive positron emission tomography response criteria in solid tumors (imPERCIST) in non small cell lung carcinoma (NSCLC) patients treated with nivolumab. Methods: 20 patients of metastatic NSCLC underwent 18F-FDG PET/CT scan prior to initiation (PET 0), after 4 cycles (...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer I Source Type: research
Conclusions: 18F-RGD PET/CT imaging revealed the presence of increased angiogenesis in the tumor microenvironment of NSCLC, especially squamous cell carcinoma, and thus may be valuable in planning therapeutic regimens for individual patients.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer II Source Type: research
Conclusions: The SUVLN on 18F-alfatide PET/CT may be the preferred parameter for predicting the survival of lung cancer.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer (Poster Session) Source Type: research
In this study, 226 patients with resected lung cancers were enrolled. DWI was performed on each patient before surgery. There were 167 patients with adenocarcinoma, 44 patients with squamous cell carcinoma, and 15 patients with other cell types. Relationships between the apparent diffusion coefficient (ADC) of DWI and the pathology were analyzed. When the optimal cutoff value (OCV) of ADC for diagnosing malignancy was 1.70 × 10−3 mm2/s, the sensitivity of DWI was 92.0% (208/226). The sensitivity was 33.3% (3/9) in mucinous adenocarcinoma. The ADC value (1.31 ± 0.32 × 10−3 mm2/s) of adenocarci...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Abstract OBJECTIVE: Non-invasive distinction between squamous cell carcinoma and adenocarcinoma subtypes of non-small-cell lung cancer (NSCLC) may be beneficial to patients unfit for invasive diagnostic procedures or when tissue is insufficient for diagnosis. The purpose of our study was to compare the performance of random forest algorithms utilizing CT radiomics and/or semantic features in classifying NSCLC. METHODS: Two thoracic radiologists scored 11 semantic features on CT scans of 106 patients with NSCLC. A set of 115 radiomics features was extracted from the CT scans. Random forest models were develope...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Conclusion: In view of the poor specificity, the current study calls for reconsideration of the universal recommendation of dedicated brain imaging (in addition to PET/CT scan) among NSCLC patients beyond stage I. PMID: 31116030 [PubMed - as supplied by publisher]
Source: Journal of Comparative Effectiveness Research - Category: General Medicine Tags: J Comp Eff Res Source Type: research
Conclusions: Hypermetabolic changes on DTP 18F-FDG PET showed good correlation with tumor positive expression of PD-L1 and high density of CD8 TILs and PD-1 in tumor immune microenvironment. Furthermore, dSUVmax was an independent predictor of PD-L1 expression in pretreated NSCLC.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer I: Molecular Biomarkers and Molecular Imaging Signatures Source Type: research
1331Purpose: To explore the relationship between 18F-FDG PET/CT derived parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG) of primary tumor and serous tumor markers, and also to assess their differences between stage Ia~IIIa and stage IIIb~IVb in different histopathologic subtypes of lung cancer. Methods: A total of 101 newly diagnosed lung cancer patients (72 males, 29 females; average age 65.5 years) with pathologically proven were retrospectively analyzed, who had undergone 18F-FDG PET/CT scan before treatment from September 2016 to February 2018....
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer Posters Source Type: research
Conclusions: Baseline MTV based parameters evaluated from primary tumor as well as the whole body tumor lesions are reliable prognostic markers of OS in NSCLC patients. Also, among the post-therapy parameters and percentage changes, whole body MTV based parameters i.e. post-TLGwb and TLGwb can predict OS of NSCLC patients.However, SUV based whole body PET/CT parameters (SUVmax, SUVavg, and TBR) evaluated from baseline as well as post-therapy scans have no prognostic value in these patients.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer Posters Source Type: research
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