Management of a pathological fracture in a rare case of Gorham Stout disease of the hip with a mega prosthesis

Publication date: Available online 21 August 2019Source: Journal of OrthopaedicsAuthor(s): Raju Vaishya, Abhishek Vaish, Lokesh Kumar Singh, Pankaj BawejaAbstractGorham-Stout disease (GSD) is a rare bone disease of unknown etiology, characterized by spontaneous and progressive resorption of bones. This disease occurs most commonly in males of the age group of fewer than 40 years and has no genetic predisposition. It most commonly affects the skull, spine, pelvis and shoulder girdle. The diagnosis of GSD is established based on the combination of clinical, radiologic, and histological features, after excluding other diseases. There is no standard treatment for it so far, and the therapy depends on patient's clinical condition and may include surgery, radiotherapy, and drugs, with varying degrees of success. To the best of our knowledge such involvement of hip and its treatment by a megaprosthesis, in an elderly lady by GSD has not been reported. This case report describes an unusual presentation of the disease of the hip in an elderly female successfully treated with replacement of the deficient proximal femur by using a bipolar hip mega prosthesis of the hip (XLO, India).
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research

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Publication date: Available online 20 September 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Ken Walder, Michael BerkAbstractActivated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric disorders including major depression, bipolar disorder and schizophrenia. They offer independent and shared contributions to pathways underpinning medical comorbidities including insulin resistance, metabolic syndrome, obesity and card...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Hi, I have been taking medicare patients for a while. lately after a local community center went bankrupt, i decided to take a few patients. One current issue I keep having is that medicare keeps denying coverage for labs like cbc, chem panel, lipids, hemoglobin A1c. The labs (quest/labcorp) don't know what it is either other than we have the wrong codes. I am using the standard codes for bipolar/schizophrenia. F31.x, F20.x etc. Anyone else having this issues/have experience with this?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Psychiatry Source Type: forums
CONCLUSIONS: These findings suggest that smoking initiation and lifetime smoking are likely to be a causal risk factor for developing bipolar disorder. We found some evidence that liability to bipolar disorder increased smoking heaviness. Given that smoking is a modifiable risk factor, these findings further support investment into smoking prevention and treatment in order to reduce mental health problems in future generations. DECLARATION OF INTEREST: W.v.d.B received fees in the past 3 years from Indivior, C&A Pharma, Opiant and Angelini. G.M.G. is a National Institute for Health Research (NIHR) Emeritus Senior Inves...
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
ConclusionOur panoramic meta-overview suggests that exercise can be an effective adjunctive treatment for improving symptoms across a broad range of mental disorders.
Source: Sports Medicine - Category: Sports Medicine Source Type: research
by Justin D. Rasmussen, Bernard Kakuhikire, Charles Baguma, Scholastic Ashaba, Christine E. Cooper-Vince, Jessica M. Perkins, David R. Bangsberg, Alexander C. Tsai BackgroundMental illness stigma is a fundamental barrier to improving mental health worldwide, but little is known about how to durably reduce it. Understanding of mental illness as a treatable medical condition may influence stigmatizing beliefs, but available evidence to inform this hypothesis has been derived solely from high-income countries. We embedded a randomized survey experiment within a whole-population cohort study in rural southwestern Uganda to ass...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
So now, according to the Washington Post, the Trump Administration is “…considering a controversial proposal to study whether mass shootings could be prevented by monitoring mentally ill people for small changes that might foretell violence.”1 As a psychiatrist, I keep wondering how many times the White House will scapegoat those with psychiatric illnesses rather than looking at the scientific data on mass shooters. To understand the problem, consider the case of “Tyler” (a composite of many mass shooter profiles). Tyler is a 19-year-old, single, unemployed high school dropout. He was wo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Criminal Justice Mental Health and Wellness Stigma Violence and Aggression extreme risk protection order mass shooting Mental Illness red flag law Source Type: blogs
Condition:   Atrial Fibrillation (AF) Interventions:   Diagnostic Test: multipolar mapping catheter;   Diagnostic Test: multielectrode circular catheter;   Diagnostic Test: irrigated ablation catheter Sponsors:   University Hospital, Basel, Switzerland;   Boston Scientific Corporation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Côrte-Real B, Andrade G, Pestana PC, Duarte TA, Martins PT PMID: 31529809 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Bipolar disorder is largely misdiagnosed. That not only hurts the person living with it, but their loved ones, too.
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Abstract Chromosome conformation capture methods have revealed the dynamics of genome architecture which is spatially organized into topologically associated domains, with gene regulation mediated by enhancer-promoter pairs in chromatin space. New evidence shows that endogenous hormones and several xenobiotics act within circumscribed topological domains of the spatial genome, impacting subsets of the chromatin contacts of enhancer-gene promoter pairs in cis and trans Results from the National Institutes of Health-funded PsychENCODE project and the study of chromatin remodeling complexes have converged to provide ...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rev Source Type: research
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