MicroRNA ‑208a directly targets Src kinase signaling inhibitor 1 to facilitate cell proliferation and invasion in non‑small cell lung cancer.

MicroRNA‑208a directly targets Src kinase signaling inhibitor 1 to facilitate cell proliferation and invasion in non‑small cell lung cancer. Mol Med Rep. 2019 Jul 31;: Authors: Liu L, Wang W, Gao S, Wang X Abstract The abnormal expression of microRNAs (miRNAs/miRs) has a critical function in the formation and progression of non‑small cell lung cancer (NSCLC). Therefore, understanding the association between NSCLC and dysregulated miRNAs may allow for the identification of novel diagnostic and therapeutic biomarkers for patients with this malignancy. Previous studies have validated miR‑208a as a cancer‑associated miRNA in multiple different types of human cancer, however, its expression pattern and precise function in NSCLC remains yet to be elucidated. Therefore, the aims of the present study were to measure miR‑208a expression in NSCLC, investigate its specific functions in NSCLC and determine its exact regulatory mechanisms. Herein, the results demonstrated that miR‑208a was significantly upregulated in NSCLC tissues and cell lines compared with that in adjacent non‑cancerous tissues and a non‑tumorigenic bronchial epithelium BEAS‑2B cell line (P<0.05, respectively). The high expression level of miR‑208a exhibited an obvious association with Tumor‑Node‑Metastasis stage and lymph node metastasis. MiR‑208a silencing decreased the proliferative and invasive capacities of NSCLC cells. Notably, Src kinase ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research