Brown fat filters branched-chain amino acids

Brown fat helps protect against obesity and diabetes by filtering branched-chain amino acids from the blood, according to research published inNature.Medical Xpress
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Publication date: Available online 18 November 2019Source: PeptidesAuthor(s): Rabeet Khan, Alejandra Tomas, Guy A. RutterAbstractGlucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin that, in common with glucagon-like peptide-1 (GLP-1), has both insulin releasing and extra-pancreatic glucoregulatory actions. GIP is released in response to glucose or fat absorption and acts on the GIP receptor (GIPR) to potentiate insulin release from pancreatic beta cells. GIP has also been shown to promote beta cell survival and stimulate the release of GLP-1 from islet alpha cells. There is now evidence to suggest ...
Source: Peptides - Category: Biochemistry Source Type: research
Authors: Doulberis M, Papaefthymiou A, Polyzos SA, Katsinelos P, Grigoriadis N, Srivastava DS, Kountouras J Abstract Obese or overweight people exceed one-third of the global population and obesity along with diabetes mellitus consist basic components of metabolic syndrome, both of which are known cardio-cerebrovascular risk factors with detrimental consequences. These data signify the pandemic character of obesity and the necessity for effective treatments. Substantial advances have been accomplished in preclinical research of obesity by using animal models, which mimic the human disease. In particular, rodent mod...
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Authors: Xiong Q, Liu J, Xu Y Abstract With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications throu...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
AR, López-Hernández Y Abstract Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide. Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders. However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesi...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
The objective of this study is the generation of descriptive data on the mode of delivery and on maternal and foetal complications in the case of foetal macrosomia. The causes and consequences of foetal macrosomia as well as the rate of shoulder dystocia are examined in relation to the severity of the macrosomia. Patients The study investigated all singleton births ≥ 37 + 0 weeks of pregnancy with a birth weight ≥ 4000 g at the Charité University Medicine Berlin (Campus Mitte 2001 - 2017, Campus Virchow Klinikum 2014 - 2017). Results 2277 consecutive newborns (birth w...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
Authors: Weschenfelder F, Lehmann T, Schleussner E, Groten T Abstract Introduction The birth of a large for gestational age (LGA) infant is a significant risk factor for birth complications and maternal morbidity and an even higher risk factor for offspring obesity, metabolic syndrome and cardiovascular disease in later life. Relevant factors affecting the risk of delivering an LGA infant are maternal pre-gravid obesity, excessive gestational weight gain exceeding the recommendations of the Institute of Medicine (IOM) and diabetes in pregnancy. We aimed to determine what matters most in terms of the risk of fetal o...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
Publication date: Available online 19 November 2019Source: The Journal of Foot and Ankle SurgeryAuthor(s): Ali A. Malik, Elaine Grant, Joshua RhodenizerAbstractThe isolated talonavicular joint arthrodesis can be beneficial to correct midfoot deformities involving the talonavicular joint, including collapsing pes planovalgus. Studies show that isolated talonavicular arthrodesis has a higher nonunion rate because of micromotion; thus, other procedures should be used in conjunction with it. We sought to determine if adding an adjunctive medial calcaneal displacement osteotomy helps to reduce the ground reactive force and, the...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
ConclusionsThe fast-food and refined grains/poultry dietary patterns were associated with high prevalence of CVD risk factors among Kuwaiti adults. The current findings underscore the need for prospective studies to further explore dietary pattern and CVD risk factor relationships among at-risk Kuwait adults.
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
Authors: Wu X, Wang Z Abstract Hypertension is an important global health concern. The relationship between hypertension and socioeconomic status (SES) has been extensively studied. However, the role of SES in hypertension is still controversial, and this kind of study is sorely lacking among Chinese middle-aged and elderly individuals. The data of this study come from the China Health and Retirement Longitudinal Survey (CHARLS) released in May 2017. A total of 21,126 people from all around China, with ages older than 45 years, were enrolled in the questionnaire survey. Hypertension was determined according to the ...
Source: International Journal of Hypertension - Category: Cardiology Tags: Int J Hypertens Source Type: research
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