MepmiRDB: a medicinal plant microRNA database

AbstractMicroRNAs (miRNAs) have been recognized as a key regulator in plant development and metabolism. Recent reports showed that the miRNAs of medicinal plants not only act as a critical modulator in secondary metabolism but also had a great potential of performing cross-kingdom gene regulation. Although several plant miRNA repositories have been publicly available, no miRNA database specific for medicinal plants has been reported to date. Here, we report the first version of MepmiRDB (medicinal plant microRNA database), which is freely accessible athttp://mepmirdb.cn/mepmirdb/index.html. This database accommodates thousands of miRNA candidates belonging to 29 medicinal plant species. The miRNA information on sequences, expression patterns and regulatory networks has been included in the functional modules of the database. Specifically, the ‘Sequence’ module provides the sequences of the mature miRNAs and their precursors, and the structure information of the precursors. Moreover, the processing and small RNA accumulation signals on the miRNA precursors are also included in the ‘Sequence’ module. The organ/growth condition-spec ific expression information of the mature miRNAs has been stored in the ‘Expression’ module. The ‘Interaction’ module offers the information of the degradome-validated miRNA—target pairs of eight plant species. The ‘Search’ module enables users to search for the miRNAs by plant species and miRNA families, or by sequences. All da...
Source: Database : The Journal of Biological Databases and Curation - Category: Databases & Libraries Source Type: research