The impact of cardiovascular diseases and new gene variants in swaying Alzheimer ’s disease

Commentary on ‘Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing’ by Nöthenet al.,Nat Genet, 2019.1
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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Publication date: Available online 26 January 2020Source: NeuroImage: ClinicalAuthor(s): Joseph Giorgio, Susan Landau, William Jagust, Peter Tino, Zoe Kourtzi, for the Alzheimer's Disease Neuroimaging InitiativeAbstractAlzheimer's disease (AD) is characterised by a dynamic process of neurocognitive changes from normal cognition to mild cognitive impairment (MCI) and progression to dementia. However, not all individuals with MCI develop dementia. Predicting whether individuals with MCI will decline (i.e. progressive MCI) or remain stable (i.e. stable MCI) is impeded by patient heterogeneity due to comorbidities that may lea...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
In conclusion, advance directives are important to avoid unwanted medical interventions, including simple interventions to address life-threatening conditions. But advance directives cannot preclude someone from entering dementia—to do that, one needs to consider VSED while having capacity. At the point of dementia, standard of care comfort care, with an appropriate strategy of feeding, should be provided.  
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: End of Life Care Health Care advance directives Author: Shelton dementia syndicated Source Type: blogs
MONDAY, Jan. 27, 2020 -- A gene mutation implicated in the risk for Alzheimer's disease might also impair memory in soccer players who head the ball a lot, a new study suggests. The finding could have implications for young athletes in contact...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
With the caveat that the behavior of cells in culture is not necessarily all that relevant to their behavior amidst the full complexities of living tissue, this study is an interesting initial exploration of the ways in which the cellular senescence of supporting cells in the brain might contribute to the progression of neurodegeneration. Senescent cells secrete a potent mix of inflammatory and other signaling; while they serve a useful purpose when present for a short time, not all are successfully destroyed. Their numbers grow with age, and the presence of these errant cells and their signaling is very harmful over the l...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Funding Opportunity RFA-AG-21-012 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites U24 Cooperative Agreement applications aiming to establish several mis-folded protein polymorphisms resource networks in the area of Alzheimer's disease and its related dementias (AD/ADRD). The central goal of these resource networks is to standardize and distribute seed, oligomers, and fibrils to other investigators in order to clarify and improve the reproducibility of experiments in AD/ADRD. For the past several years, many studies have developed assays and reagents to understand the biophy...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01974
Source: Analytical Chemistry - Category: Chemistry Authors: Source Type: research
(IOS Press) In a study published in the Journal of Alzheimer's Disease, ISS researchers estimated about 680,000 cases of mild cognitive impairment (MCI), in a total of 12,730,960 migrants, aged between 60 and 89 years, living in the European Union (EU) in 2018.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Cold Spring Harbor Laboratory) Large holes in our cells have been implicated in depression, Alzehimer's disease, asthma, and even taste. Now, we know what two kinds of these pores look like, potentially creating new opportunities to discover effective treatment options.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Choi Inflammasomes are intracellular multiprotein complexes in the cytoplasm that regulate inflammation activation in the innate immune system in response to pathogens and to host self-derived molecules. Recent advances greatly improved our understanding of the activation of nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasomes at the molecular level. The NLRP3 belongs to the subfamily of NLRP which activates caspase 1, thus causing the production of proinflammatory cytokines (interleukin 1β and interleukin 18) and pyroptosis. This inflammasome i...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
Insisting you are right because, well, you know better. You don’t have dementia. People living with dementia (PLWD) have an increasingly limited ability to understand the world as we see it. Therefore, we need to learn to see the world from their view. When we do this, we don’t argue if they say that they haven’t eaten all day even though lunch was an hour ago. We just say, “Really? Then we’d better get you a snack.” View slideshow on HealthCentral to learn more about how avoiding certain mistakes while caring for someone who lives with dementia can make everyone's life easier: Caro...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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