Corrigendum to: 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias

Corrigendum to: 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias [Europace 2019;21:1143 –1144]
Source: Europace - Category: Cardiology Source Type: research

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AbstractMinesapride (drug code: DSP ‐6952) is a potential gastrointestinal prokinetic agent with high selectivity for 5‐hydroxytryptamine 4 (5‐HT4) receptor that acts as a partial agonist. Although 5 ‐HT4 receptor agonists are expected to show efficacy in patients with irritable bowel syndrome with constipation, only tegaserod is available for female patients, with limitations, in the United States. Previously, another 5 ‐HT4 receptor agonist, cisapride, was widely used for the treatment of upper gastrointestinal diseases, but was withdrawn from the market because of arrhythmia with QT prolongation. Chemically, b...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
ConclusionsFetuses with structurally normal hearts and sustained SVT can be effectively managed with transplacental drug therapy with minimal risk of intrauterine fetal demise. Treatment requires multiple anti ‐arrhythmic agents in over half of cases. Later gestational age at fetal diagnosis and the presence of depressed fetal ventricular function, but not hydrops, predict postnatal arrhythmia burden.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 27 February 2020Source: Forensic Science International: GeneticsAuthor(s): Germaine Liebrechts-Akkerman, Fan Liu, Ronald van Marion, Winand N.M. Dinjens, Manfred Kayser
Source: Forensic Science International: Genetics - Category: Forensic Medicine Source Type: research
Catheter ablation has been considered an effective strategy for the treatment of ventricular arrhythmias (VA) originating from the left ventricular summit (LVS). However, the inherent complexity of the anatomy of the LVS may result in failed ablation or recurrence of VA.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
Hypertrophic cardiomyopathy (HCM) carries an increased risk of sudden death due to ventricular arrhythmias (VA). The implantable defibrillator (ICD) is a well-established therapy to treat VA. Monomorphic ventricular tachycardias (MVT) are frequent in HCM patients and suitable for antitachycardia pacing (ATP) termination.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
Recent studies for cardiac cell-based therapy have demonstrated significant improvements in cardiac function. However, there are high incidences of ventricular arrhythmias in animal models of myocardial infarction (MI) injected with pluripotent stem cell-derived cardiomyocytes (PSC-CMs). The current study by Yu et  al (Sci Rep 2019; 9:9238; PMID: 31239508) examined the underlying mechanisms of arrhythmogenesis. The authors provided a comprehensive computational modeling of direct remuscularization approaches to cell therapy using multiscale 3D whole-heart modeling integrating representations of cell delivery and trans...
Source: Heart Rhythm - Category: Cardiology Authors: Tags: EP NEWS Source Type: research
The Advanced Cardiac Life Support algorithm for ventricular fibrillation (VF) and pulseless ventricular tachycardia (pVT) includes adrenaline (epinephrine).1 Through its peripherally vasoconstrictive alpha-adrenergic effect, blood flow is redirected centrally, improving coronary perfusion. Adrenaline ’s beta-adrenergic effect however, may be harmful. It increases myocardial sensitivity to arrhythmias, potentially leading to cardiovascular collapse from refractory pVT/VF.2,3 Therefore, there is a need to investigate potential therapies that may counteract adrenaline’s deleterious effects.
Source: Resuscitation - Category: Emergency Medicine Authors: Tags: Letter to the Editor Source Type: research
This was sent by a reader:" I would really appreciate your thoughts on this ekg progression. 71 yo F, only risk factor hyperlipidemia, has isolated chest discomfort, non-exertional and non-radiating. "Sinus rhythm with one PVC.What do you think?Smith response:This ECG has symmetric (hyperacute) T-waves in V2-V4.  It is diagnostic of LAD occlusion.If you're uncertain, use theformula: https://hqmeded-ecg.blogspot.com/2017/11/12-cases-of-use-of-3-and-4-variable.htmlI applied it here after measuring a QTc of 440 ms.The value comes to 19.73 (greater than 18.2 is quite good for Diagnosis of LAD occlusion...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
Conclusions: Esophageal wire traction shortens the clearance time for the left recurrent laryngeal nerve lymph nodes, reduces thoracic bleeding, and improves the quality of left recurrent laryngeal nerve lymph node dissection in three-hole thoracoscopic esophagectomy. PMID: 32091290 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
New Brunswick, NJ, February 25, 2020 — Johnson &Johnson (NYSE: JNJ) today announced that the Janssen Pharmaceutical Companies of Johnson &Johnson, in collaboration with Apple, opened enrollment for the Heartline™ Study. The study is designed to explore if the Heartline™ Study app on iPhone and heart health features on Apple Watch can improve health outcomes, including reducing the risk of stroke, with earlier detection of atrial fibrillation (AFib). AFib, a common form of irregular heart rhythm, is a leading cause of stroke in the U.S. To enroll in the Heartline™ Study, individuals must be a...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
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