Full Chemo Doses Early On Maximize Breast Cancer Survival Full Chemo Doses Early On Maximize Breast Cancer Survival

' The juice is worth the squeeze,'say experts, who warn against reducing the dose of adjuvant chemotherapy because it may lower survival.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

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Conclusions: Mortalin promotes cell proliferation, metastasis, angiogenesis, downregulate apoptotic signaling. Thus, mortalin is a potential therapeutic target for cancer immunotherapy. The novel SMRwt peptides antagonize the functions of mortalin, blocking tumor extracellular vesicle release and extracellular vesicle-mediated release of complement. This leads to decreases in breast cancer cell metastasis and allows standard treatment of these late stage tumor cells, thus having important clinical implications for late stage breast cancer chemotherapy. These findings support further investigation into the therapeutic value...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusions: Increased NK cells after NAC, together with increased CD4+ and CD8+ T-cells, and decreased CTLA-4+ T cells and VEGF correlate with beneficial therapeutic effects. Systemic activation of pNK cell activity and the presence of pre-NAC TILs may improve the elimination of Ax + together with decreased immunosuppression by VEGF in tumors.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Condition:   Triple Negative Breast Cancer Interventions:   Drug: Docetaxel;   Drug: Doxorubicin;   Drug: Cyclophosphamide;   Drug: Pembrolizumab;   Drug: IL-12 gene therapy;   Drug: L-NMMA Sponsors:   The Methodist Hospital System;   Merck Sharp & Dohme Corp. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
I defeated breast cancer, but am still battling the cognitive changes left behind after two years of intense treatment. Eight surgeries, six chemotherapy treatments, 25 radiation appointments, and two bouts of infection changed my body forever. I’m OK with that, because everything was done to keep me alive. All signs point to these efforts succeeding. But one remnant of the battle didn’t get left behind with the wigs and empty medicine bottles: chemo brain. “Chemo brain” is a common term used for the attention and memory issues often caused by cancer treatment—although these issues are thought...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Health Care Private Practice Slider Speech-Language Pathology Cognitive Rehabilitation Source Type: blogs
This study assesses the clinical effect of SFI combined with chemotherapy for breast cancer patients. Materials and methods: Both English and Chinese databases were searched covering the time period of 1999- 2018 for relevant studies comparing the effect of SFI plus chemotherapy treatment with chemotherapy alone in patients with breast cancer. Target outcomes concerning treatment effect, performance status, immune system and toxic effects were extracted and combined using Stata version 15.0 software. Quality assessment was performed using the Jadad scale. Results: Forty-nine trials were included based on certain selection ...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
This 61-year-old woman presented with new primary triple negative breast cancer (TNBC) in the lateral breast 10 years after completing radiation for ductal carcinoma in situ (DCIS) in the same breast.1 Despite neoadjuvant chemotherapy and mastectomy with only residual DCIS and negative nodes, patient developed a TNBC re-recurrence only 9 months later. She was treated with chemotherapy, and there remains positive residual localized disease by positron emission tomography (PET). At this point we recommend the following.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Yu-Hui Zhou, Yang Liu, Wei Zhang, Chao Liu, Jian-Jun He, Xiao-Jiang TangABSTRACTBackgroundChemotherapy is the predominant treatment option for patients with breast cancer. Selection of patients according to biomarker will improve chemotherapy efficacy. In the present study, we examined the relations of the expression of candidate genes and 21-recurrence score (RS) results to patients’ demographic characteristics, histopathological factors, and outcomes.MethodsA total of 146 patients were enrolled in this study. The...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Breast reconstruction after nipple sparing mastectomy (NSM) plays, nowadays, a fundamental role in breast cancer management. There is no consensus on the best implant-based reconstruction technique, considering 2 stages (expander-prosthesis) or direct-to-implant (DTI). A retrospective review of consecutive adult female patients who underwent NSM with breast reconstruction over a 3-year period (January 2013 to December 2015) was performed. Patients were divided into 2 groups according to the type of reconstruction: expander/prosthesis (group A) and DTI (group B). Anamnestic data were collected. Number and type of procedures...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Breast Surgery Source Type: research
New research from Tulane University found that some breast cancer cells become 'cannibals' and, instead of multiplying, engulf neighboring cells to stock up on energy in order to dodge chemo.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
British Journal of Cancer, Published online: 17 September 2019; doi:10.1038/s41416-019-0576-5Comment on: “Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp-cooling system in early breast cancer patients treated with anthracyclines”
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
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