G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub.

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub.
Cell Mol Life Sci. 2019 Aug 20;:
Authors: Penela P, Ribas C, Sánchez-Madrid F, Mayor F
Abstract
Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain structure and from complex mechanisms of regulation of its expression levels, activity, and localization within the cell, what allows the precise spatio-temporal shaping of GRK2 targets. A better understanding of the GRK2 interactome and its modulation mechanisms is helping to identify the GRK2-interacting proteins and its substrates involved in the participation of this kinase in different cellular processes and pathophysiological contexts.
PMID: 31432234 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - August 19, 2019 Category: Cytology Authors: Penela P, Ribas C, Sánchez-Madrid F, Mayor F Tags: Cell Mol Life Sci Source Type: research