Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions
Mast cells (MCs) are capable of executing powerful inflammatory response programs triggered by surface IgE cross-linking or through pattern recognition receptors. The question of how MCs contribute to human disease has been intensely investigated and stimulated much controversy. Correlative evidence comes from human studies, pointing to pathogenetic or protective MC functions in patients with atopic conditions, autoimmune disorders, type 2 diabetes, chronic urticaria, mastocytosis, and cancer. Experiments in MC-deficient mice underpinned key roles for MCs in patients with IgE-mediated allergic conditions.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Marcus Maurer, Christian Taube, Nicolas W.J. Schr öder, Jörg Ebmeyer, Frank Siebenhaar, Astrid Geldmacher, Nadja Schubert, Axel Roers Source Type: research
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