Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1

Jung et  al. identify an mTORC2-SIRT6-FoxO1 pathway in brown adipocyte that suppresses lipid catabolism and UCP1 expression independently of mTORC2’s role in promoting de novo lipogenesis. Mice lacking brown fat mTORC2 are protected against diet-induced obesity, uncovering a new mechanism in brown fat th at regulates systemic metabolic homeostasis.

Source: Molecular Cell - August 21, 2019 Category: Cytology Authors: Su Myung Jung, Chien-Min Hung, Samuel R. Hildebrand, Joan Sanchez-Gurmaches, Barbara Martinez-Pastor, Jivani M. Gengatharan, Martina Wallace, Dimpi Mukhopadhyay, Camila Martinez Calejman, Amelia K. Luciano, Wen-Yu Hsiao, Yuefeng Tang, Huawei Li, Danette L Tags: Article Source Type: research