SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

Panier et  al. reveal that SLX4IP is a regulator of ALT telomere maintenance that binds to both BLM and SLX4 and influences the balance between resolution and dissolution at recombining telomeres. Its importance for the ALT process is underscored by the finding that SLX4IP is inactivated in a subset of ALT-p ositive osteosarcomas.

Source: Molecular Cell - August 21, 2019 Category: Cytology Authors: Stephanie Panier, Marija Maric, Graeme Hewitt, Emily Mason-Osann, Himabindu Gali, Anqi Dai, Adam Labadorf, Jean-Hugues Guervilly, Philip Ruis, Sandra Segura-Bayona, Ondrej Belan, Paulina Marzec, Pierre-Henri L. Gaillard, Rachel L. Flynn, Simon J. Boulton Tags: Article Source Type: research