Low Antibody Response Seen With RA Drug (CME/CE)

(MedPage Today) -- Few rheumatoid arthritis patients treated with abatacept (Orencia) developed immunogenic responses that could interfere with efficacy and safety of the biologic agent, an international study found.
Source: MedPage Today Geriatrics - Category: Geriatrics Source Type: news

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ConclusionsTocilizumab appears to be effective and safe in RA in clinical practice. The optimised regimen appears to be effective in most patients in remission, even when they change from IV to SC.ResumenObjetivoEvaluar la efectividad y la seguridad de tocilizumab (TCZ) en pacientes con artritis reumatoide (AR) en práctica clínica; la optimización de dosis y el cambio de formulación intravenosa (iv) a subcutánea (sc).Material y métodosEstudio observacional retrospectivo. Se incluyó a 53 pacientes con AR tratados con TCZ. El desenlace principal fue efectividad de TCZ en la se...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Publication date: Available online 20 September 2018Source: Best Practice &Research Clinical RheumatologyAuthor(s): Jonathan Chan, Dafna GladmanAbstractSpondyloarthritis (SpA) represents a group of common diseases that share a number of characteristic clinical manifestations including peripheral arthritis, spondylitis, enthesitis, and dactylitis. Additionally, they can often be associated with extra-articular manifestations including psoriasis, anterior uveitis, and inflammatory bowel disease. The two most widely studied clinical phenotypes are ankylosing spondylitis and psoriatic arthritis.Although a number of biologi...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Adalimumab, a fully human antibody to tumor necrosis factor (TNF), was first approved by the Food and Drug Administration (FDA) in 2002 for the treatment of rheumatoid arthritis. In 2008, it was approved for treatment of polyarthritis juvenile idiopathic arthritis and has since been approved for other pediatric indications that cross several subspecialties, including dermatology, gastroenterology and ophthalmology. Thus, it is important for a growing number of pediatricians, including those in primary care, to be aware of the safety profile of this widely used biologic medication.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
ConclusionGene expression of IL6 was down-regulated in RA patients, especially CRP-negative patients. Moreover, four SNPs of such cytokine may have a role in RA risk.
Source: Alexandria Journal of Medicine - Category: General Medicine Source Type: research
Manoela Manova, Alexandra Savova, Maria Vasileva, Silvia Terezova, Maria Kamusheva, Daniela Grekova, Valentina Petkova, Guenka Petrova
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 11 September 2018Source: Autoimmunity ReviewsAuthor(s): Dennis McGonagle, Abdulla Watad, Sinisa SavicAbstractThe classical autoimmunity paradigm in rheumatoid arthritis (RA) is strongly supported by immunogenetics suggesting follicular helper T-cell responses driving high titre specific autoantibodies that pre-dates disease onset. Using the immunological disease continuum model of inflammation against self with “pure” adaptive and innate immune disease at opposite boundaries, we propose a novel immune mechanistic classification describing the heterogeneity within RA. Mutations...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: Available online 19 September 2018Source: Journal of Advanced ResearchAuthor(s): Luca Quartuccio, Alen Zabotti, Stefania Del Zotto, Loris Zanier, Salvatore De Vita, Francesca ValentAbstractRisk of hospitalized infections under biologics among patients suffering from chronic inflammatory autoimmune diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PSA), or psoriasis was investigated using administrative data. The hospital discharge records database, the medical prescription database, and the database of exemptions from medical charges were linked at the individua...
Source: Journal of Advanced Research - Category: Research Source Type: research
THURSDAY, Sept. 20, 2018 -- Different from osteoarthritis, which is the wear-and-tear breakdown of joint cartilage experienced over time, rheumatoid arthritis, or RA, is an autoimmune disease that causes both pain and intense fatigue. When you're in...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Investigation of Lake Hévíz Mineral Water Balneotherapy and Hévíz Mud Treatment in Murine Osteoarthritis and Rheumatoid Arthritis Models. Evid Based Complement Alternat Med. 2018;2018:4816905 Authors: Tékus V, Borbély É, Kiss T, Perkecz A, Kemény Á, Horváth J, Kvarda A, Pintér E Abstract Arthritic diseases are the most frequent causes of chronic pain and disability. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and progressive structural joint damage. Osteoarthritis is a degenerative...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
ConclusionsThe chemical and biological properties of SO, SP and SG were different and distinctive. They might be reasonably applied in clinic for the management of rheumatism/-related diseases.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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